Locally Advanced Non-small Cell Lung Cancer Recurrence After Radiotherapy And Chemotherapy Related Factors

Objective: To explore the local recurrence and distant metastasis of clinicopathologic factors of locally advanced non-small cell lung cancer after radiotherapy and chemotherapy. Methods:A retrospective analysis of recurrence of clinical data and related factors of 260 cases in our hospital and diagnosed by pathology and chemotherapy or combined chemo-radiotherapy for locally advanced non-small cell lung cancer patients. Results:1.219 patients (local recurrence and distant metastasis)after treatment relapsed in 260 patients with locally advanced lung cancer, accounting for 84.23%(219/260), of which 85 patients with local recurrence, accounting for 32.69%(85/260); 134 patients with distant metastasis, accounting for 51.54%(134/260); 2.Univariate analysis showed that clinical and pathological data: age, CEA, anemia, platelet levels, clinical stage, T stage, N stage, treatment, curative effect, numbers of chemotherapy cycles,were related with lung cancer recurrence (P<0.2); 3. Multivariate analysis showed that: high CEA level, increased platelet levels,late clinical stage were important risk factors of lung cancer recurrence (P<0.05, OR values> 1), and the high CEA level, platelet levels, late clinical stage were risk factors of distant metastasis (P<0.05, OR values>1); numbers of chemotherapy cycles, combined chemo-radiotherapy were protective factors for lung cancer recurrence (P<0.05, OR values<1); especially numbers of chemotherapy cycles was protective factor for lung cancer metastasis (P<0.05, OR values<1). Conclusion: The locally advanced non-small cell lung cancer the vast majority of patients relapsed after treatment, in clinicopathologic factors, protective factors included numbers of chemotherapy cycles, radiotherapy and combined chemo-radiotherapy, prompted the relevant factors of lung cancer recurrence included high CEA level, increased platelet levels, late clinical stage.