| Background Inflammatory bowel disease (IBD) is a chronic, recurrent, non-specific gastrointestinal inflammatory disease, mainly including ulcerative colitis (UC) and Crohn's disease (CD). Because of inadequate nutrient intake, intestinal malabsorption, loss increased, energy consumption increased, drug nutrient interactions and inflammatory effects on nutritional status itself, IBD patients have a higher incidence of malnutrition. Therefore, nutritional risk is screened to improve the IBD patients'nutritional status of the whole and the local intestinal through early nutrition intervention. It is an important link in the treatment and the rehabilitation of IBD.Objective This study adopted NRS 2002 to screen the nutritional risk of hospitalized patients with active UC, and analyze the correlation between nutritional risk and clinical features of UC.Methods 54 hospitalized patients with active UC and 25 normal controls were collected at Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University from June 2009 to November 2010. Refer to"Survey case of ulcerative colitis"formulated by the national IBD Consortium to register and analyze the clinical features of UC, and screen the nutritional risk through NRS 2002.Using Chen Chunming BMI standard, BMI <18.5kg/m2 is defined as low weight. If BMI of patients can not be recorded, serum albumin values would be replaced. The remaining was fully consistent with the NRS 2002. Modified Baron endoscopic grading was referred by grading standards. Results All these 54 active patients were evaluated by NRS 2002, 20 patients (37.0%) were judged at the risk of malnutrition risk. In the 20 patients with malnutrition risk, according to the clinical types of UC, 10.0% were first episode, 70.0% were chronic relapse, 15.0% were chronic persistent and 5.0% were acute fulminant of UC. The incidence of 5.0%, 40.0%, and 55.0% was found in the malnutrition risk patients with mild, moderate and severe activity, respectively. According to the distribution of disease, 10.0% were proctosigmoiditis, 20.0% were left-sided colitis, 20.0% were extensive colitis and 50.0% were pancolitis, respectively (P<0.05). The incidence of malnutrition risk was no correlated with age, sex, extra-intestinal manifestations, complications or endoscopic grade.Conclusions (1) NRS 2002 contributes to identify nutritional risk in hospitalized UC patients; (2) The incidence of malnutrition risk is high in UC patients by NRS 2002; (3) It is correlated with nutritional risk of hospitalized UC patients and the clinical features including the clinical types, the severity and the extent of colonic involvement. Background Osteoporosis (OP) is one of common and easily overlooked complications in patients with IBD. Early detection of the level of bone metabolism in IBD patients contribute to the assessment and treatment of IBD-related OP.Objective Deoxypyridinoline (DPD), osteocalcin (OC) commonly used as bone metabolic markers in screening and evaluation of OP. Therefore, it is necessary to investigate the level of DPD, OC and Ghrelin of UC patients and their clinical significance.Methods All clinical data of 54 active UC patients were collected, which was the same to Part 1, the level of urinary deoxypyridinoline (DPD), serum osteocalcin (OC) and Ghrelin were examined by enzyme-linked immunosorbent adsorption (ELISA) and 25 normal subjects as control, while urinary creatinine adjusted urinary DPD, respectively, and the correlation was analyzed between the clinical features and nutritional risk of UC.Results The level of urinary DPD/Cr in active UC patients was significantly higher than that in the control group(13.56±3.50 nmol/mmo1 vs 6.71±1.95 nmol/mmo1, P<0.05), the level of serum OC in active UC patients was significantly lower than that in the control group(1.58±0.64ng/ml vs 2.42±0.72ng/ml, P<0.05) and the level of serum Ghrelin in active UC patients was not statistically significant(1079.43±351.06pg/m1 vs 1058.87±336.21 pg/ml, P>0.05).According to Nutritional Risk Screening2002(NRS 2002), the level of urinary DPD/Cr in active UC patients was significantly difference between positive and negative nutritional risk group(16.17±3.37nmol/mmo1 vs 12.03±2.58nmol/mmo1, P<0.05). Serum Ghrelin was significantly differences between positive and negative nutritional risk group (1222.10±237.90pg/ml vs 995.51±381.78pg/ml, P<0.05). According to the distribution of disease, the level of serum OC in active UC patients with proctitis, proctosigmoiditis, left-sided colitis, extensive colitis and pancolitis groups were significantly difference (P<0.05) .The level of serum Ghrelin in active UC patients between mild, moderate and severe groups were significantly difference (P<0.05).The level of urinary DPD/Cr, serum OC and Ghrelin were not correlated with the clinical type and the endoscopic grading in UC groups (P>0.05).Conclusions (1) The level of urinary DPD/Cr is higher than the normal control group, serum OC is lower and Ghrelin was not statistically significant between patients with active UC and the normal control group; (2) The level of urinary DPD/Cr and serum OC contributes to assessing the status of bone metabolism in patients with UC; (3) It is correlated with urinary DPD/Cr, serum OC, Ghrelin levels and the clinical features including the severity, the extent of colonic involvement and nutritional risk.
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