The Investigation To High-pressure Ozone Treatment In Patients With Intracebral Hemorrhage After Micro-invasive Puncture Surgery

Objective:(1) To investigate the safety and feasibility of clinical application of high-pressure ozone treatment in patients with intracebral hemorrhage after micro-invasive puncture surgery; (2) To investigate high-pressure ozone treatment on the survivals of patients with intracerebral hemorrhage after after micro-invasive puncture surgery (3) To investigate relevance of myelin basic protein (MBP) level and neurological deficit (NIHSS) score after instracerebral hemorrhage (4) To investigate high-pressure ozone treatment whether have influence to hospitalization expense and hospitalization time in patients with intracebral hemorrhage after micro-invasive puncture surgery (5) To combine pressure-ozone treatment and broaden the idea of consolidation therapy for intracerebral hemorrhage after micro-invasive puncture surgery.Method:Between 2010/03 and 2011/03,40 patients were selected at Department of Neurology of our hospital, who were proved to be the first basal ganglia cerebral hemorrhage by CT examination, bleeding volume 30ml-90ml,<24h from onset. According to permission all cases were divided into the control group with conventional micro-invasive puncture surgery and the treatment group with high-pressure ozone treatment after micro-invasive puncture surgery. The levels of myelin basic protein (MBP) in plasm and neurological deficit(NIHSS) of patients were respectively measured on preoperative and the third day,the seventh day,the fourteenth day,the twenty-eighth day after surgery. The glasgow coma scale (GCS) of patients was respectively evaluated on preoperative and the seventh day,the fourteenth day,the twenty-eighth day after surgery. Line correlation analysis of MBP levels and NIHSS scores on preoperative and the seventh day,the fourteenth day after surgery was carried out. Record the two group hospitalization expense and hospitalization time, then analyze whether they have statistical difference.Results:MBP levels and NIHSS scores in treatment group and control group were no significant difference(P>0.05)on third day after surgery. On the seventh day,the fourteenth day,the thirtieth day after surgery the MBP levels and NIHSS scores in treatment group were significantly lower than in the control group(P<0.05). On the seventh day after surgery the GCS scores of two groups were no statistical significance(P>0.05). The GCS scores of two groups were statistically significant comparison (P<0.05)on the fourteenth day, the thirtieth day after surgery. The MBP levels in plasma and NIHSS scores were positively correlated(P<0.05)on preoperative and the seventh day,the fourteenth day after surgery.Two group patients hospitalized days is of significance in statistics science (P<0.05), but the hospitalization expense is not of significance in statistics(P>0.05).