Pathological Analysis And Risk Assessment Of Renal Biopsy In Patients With Renal Dysfunction

Objective:To analyze renal pathology and complications of renal biopsy in patients with renal dysfunction and its diagnostic value and risk factors.Methods:We retrospectively analyzed clinical data, ultrasound imaging and laboratory data of 311patients clinically manifestations as renal dysfunction (acute or chronic).1717 cases with normal renal function over the same period were as control. The pathological results and complications of renal biopsy as well as the risk factors were analyzed by multivariate analysis method.Results:89 patients with acute renal dysfunction and 222 with chronic renal dysfunction were enrolled. The top three pathological types of acute renal dysfunction were ANCA associated glomerulonephritis, acute tubular necrosis, acute interstitial nephritis. The top three pathological types of chronic renal dysfunction were IgA nephropathy, chronic tubulointerstitial damage and hypertensive renal disease. Incidence of renal biopsy complications in acute or chronic renal dysfunction were 2.2% and 5.8%, respectively, which were higher than those with normal renal function (1.3%). The incidence of patients by blood purification was 2 in 53, which was not higher than those without blood purification. However, there was no nephrectomy, death or other serious complications. Multivariate analysis showed that glomerular filtration rate was significantly associated with the incidence of complications (P= 0.032).Conclusion:Performance of renal biopsy carefully in patients with renal dysfuntcion brings benefit for pathological diagnosis and therapeutic strategy. Glomerular filtration rate is closely related with occurrence of the complications.