Research Of TCM Syndrome And Pathogenesis On Incipient Lung Caneer

Objective:To explore the ragulation of differentiation of symtoms and signs in incipient lung cancer,to make a useful attempt for the ultimate establishment of the standard.Methods:Through literature research, expert advice and early pre-survey,we schemed out the madicine history questionnaire,then made a retrospective investigation on incipient lung cancer patients'who hadn't make operation,radiotherapy chemotherapy medical records in the past 5 years,form the first affiliated hospital of Hunan University of Traditional Chinese Medicine (TCM).The total number of cases came to 175.We collected the general information and TCM symtom-sign,put the quantified TCM symtom-sign(including the symtoms of tougue and pulse) into the computer as syndrom variables,established the SPSS database.The general information was analysed with descriptive statistics; the regulated syndrome variables were analysed with sample cluster statistics and clustering analysis.We identified clustering quantity based on the professional knowledge, and identified the types of syndrome of each category after consulting the TCM theory and the experts'dialectcal results.Results:By clustering analysis,175 incipient lung cancer cases classified into 5 groups, including deficiency of both qi and yin(n=52),qi stagnation and blood stasis(n=36), yin deficiency with internal heat (n=31), qi deficiency and phlegm dampness(n=30) and accumulation phlegm-heat(n=26).Factor analysis was used to analyze the correlation among 39 symptoms based on the clinical informations collected with four diagnostic methods. The first 9 principal components accounts for 68.003% of the total informations. Based on loading value of 39 syndromes on 9 components (Rotated Component Matrix),a clustering analysis was carried on to reveal the relation between these symptoms.Conclusion:The main syndrome type of incipient lung cancer include deficiency of both qi and yin,qi stagnation and blood stasis, yin deficiency with internal heat, qi deficiency and phlegm dampness and accumulation phlegm-heat. Qi deficiency is the intrinsic. Phiegm, qi stagnation and blood stasis are the main pathological changes. The distribution pattern of syndrome types with incipient lung caneer displays its basic pathogenesis of TCM. The analyzed results with factor analysis and clustering are helpful for revealing the the typical synptoms of incipient lung caneer as well as their correlations.This is useful for the syndromes differentiation and standardization of the diagnosis of incipient lung cancer.