Teh Clinical Research Of 152 Children In Hospital With EB Virus Infection

EB virus, shorts for Epstein-Barr virus, has been found more than 40 years. It is a kind of ubiquitous and virus, because EBV occurs in nearly all regions of the world and once people get infected, the virus would stay in the human being's body regardless of the immune system. The pathogenicity of EBV started from the course of infectious mononucleosis. Later it was found that EBV also causes the Burkitt's lymphoma of the high incidences in Africa. It is also associated with particular forms of cancer, particularly nasopharyngeal carcinoma, Hodgkin's lymphoma and Breast Cancer, etc. Therefore, EBV becomes a notorious virus that it can produce multiple tumors.Epidemiology studies taken in the highly industrialized and developed countries and organizations have shown that about half of primary EBV infections occur in the children from 1 to 5 years old, the other half occurred in the ones from 10 to 20 years old. EBV infection is closely related with the socio-economic status. Poor sanitation makes more infants infect while good sanitary condition help the infant avoid the infection until they step into the adolescence period. Studies have shown that, the Japanese urban children aged from 5 to 9,EBV-positive seroconversion rate decreased from 80% in 1990 to 59% from 1995 to 1999 because of socio-economic improvement. The EBV infection is worse in our country for China is still a developing country. The epidemiological data in 1980s shows that 80.7% to 100% of the children from 3 to 5 years old EBV-positive, and 100% for the age of 10. Compared with the 1980s, our country has taken tremendous progress in economic development. Therefore, we suppose that EBV infection of primary age children may delay, but it requires further investigation to get more information.Children infected by primary EBV may carry the virus for a long time, and the virus can exist in the body for a lifelong time. So the source of infection is the virus carriers and patients. EBV is a sort of saliva-borne virus. It is mainly transmitted through saliva. So the patients are infected by close contact, such as kiss. Spitting and blood transmitting are the minor route of transmission. EBV is quite unstable for it has never been found in the external environment.In this thesis, 827 cases were recorded. From January 2009 to December 2010 there were altogether 88 boys and 64 girls aged from one month to 13 years old suspected being infected. All of them are taken throat swabs to check by PCR, 152 cases were positive. The most common symptoms: fever of 124 cases (81.6%); Angina pain in 86 patients (56.6%); lymph nodes of 88 cases (57.9%); cough 35 cases (23%); subcutaneous hemorrhage 18 cases (11.8%), skin rash in 7 cases (4.6%), headache and vomiting in 5 cases (3.3%). The most common sign: 93 patients with pharyngeal herpes (61.2%), lymph nodes of 88 cases (57.9%), hepatosplenomegaly in 33 cases (21.7%), lung wet and dry rales in 36 cases (23.7%), anemia in 16 cases (10.5%), subcutaneous hemorrhage 18 cases (11.8%), skin rash in 7 cases (4.6%); Laboratory examination report:28 cases : Peripheral the proportion of abnormal lymphocytes in the blood≥10% 20 cases, abnormal liver function in 20 (13.2%), 24 cases: thrombocytopenia (15.8%),5 cases: pancytopenia (3.3%), 4 cases: damage in multi-organ and multi- system (2.6%);Final diagnosis: 60 cases of acute upper respiratory tract infection (39.5%), lymphadenitis, 25 cases (16.4%), infectious mononucleosis syndrome in 20 cases (l3.2%), acute bronchial inflammation or pneumonia in 18 cases (11.8%), acute thrombocytopenic purpura in 16 patients (10.5%), viral encephalitis in 5 patients (3.3%), acute non-lymphocytic leukemia in 1 case (0.7%), 5 cases of Kawasaki disease (3.3%), acute aplastic anemia in 2 cases (1.3%). Prognosis and vesting: All the patients were clinically cured and discharged except that 1 case of acute non-lymphocytic leukemia and 2 cases of acute aplastic anemia patients were treated in Beijing or other places. Conclusions: EBV infection rate in children in Changchun is 18.4%; EBV infection of male to female ratio is 1.38:1. The highest incidence of cases occurs during the summer and autumn months. The clinical manifestations of EBV are complex and diversified. In addition to the performance of typical symptoms of infectious mononucleosis, it was also seen in the primary period in the disease of respiratory, circulatory, nervous and blood. Multi-organ and multi-system damages are commonly seen. PCR method is fitting for clinical application because it is simple, highly sensitive and specified.EB virus infection is harmful to children. We can know the prevalence, clinical characteristics,traetment,prognosis and prevention of EBV by carrying out the clinical research with EBV infection. It is important and meaningful for timely and accurate clinical diagnosis and treatment. Clinicians should have a comprehensive analysis and correct diagnosis so that the infection may be made by an early specific examination and so does the reasonable treatment.