Study On The Significance Of Expression Of EGFR In Adenomyosis

Objective:To make clear the roles which EGFR played in occurrence of adenomyosis, we intended to detect the expression of them in an adenomyosis tissue microarray, and analyze the relationship of EGFR and menstrual cycle, uterine size, as well as the impact of mifepristone on the EGFR.Material and Methods:We applied tissue microarray technique and immunohistochemical method to detect the expression of EGFR in eutopic and ectopic endometrial tissues of 78 cases of adenomyosis (68 cases who not taken mifeprestone before operation and 10 cases had taken mifeprestone before operation), as well as in normal endometrial tissue of 26 cases of CINIII. Then we analyzed the relationship between the expression of EGFR and menstrual cycle, uterine size, as well as the impact of mifepristone on the EGFR. All data were processed by SPSS version 17.0 analysis software.Results:1. The difference of the positive rate of EGFR in normal, ectopic and eutopic endometrial tissues was significant (P<0.05). The positive rate of EGFR in ectopic endometrial tissues was higher than normal endometrial tissues of the CINⅢgroup (P<0.017); it was higher than in eutopic endometrial tissues (P<0.017). And then the expression of EGFR in eutopic endometrial tissues increased compared with normal endometrial tissues, but the difference was not significant (P>0.017).2. Normal endometrium in the proliferative rate of EGFR expression and secretion of the difference was not statistically significant (P>0.05); the experimental group in ectopic and eutopic endometrium proliferation of EGFR expression and secretion of the differences were not Significant (P>0.05).3. The expression of EGFR-positive rate in uterine volume>8 weeks pregnant ectopic endometrium pregnancy was increased than≤8 weeks group (P<0.05); two groups EGFR expression in eutopic endometrium was no significant difference (P>0.05). At>8 weeks pregnant endometrium in ectopic expression of EGFR-positive group compared with eutopic endometrium increased significantly (P<0.05); and≤8 weeks of pregnancy group compared with eutopic endometriotic endometrium Also increased, but not statistically significant (P>0.05).4. Treatment group in the ectopic and eutopic endometrial expression of EGFR compared with the experimental group decreased (P<0.05).Conclusion:1. EGFR involved in the pathogenesis of adenomyosis, and to ectopic than eutopic endometrial cells and normal endometrial cells have a stronger proliferation. 2. The expression of EGFR did not change with the menstrual cycle.3. Mifepristone may be falling tone EGFR in ectopic endometrium of adenomyosis tissues.