Expression Of Mesothilin And KAI1 In Endometrial Carcinoma And Clinical Value

Background and ObjectivesEndometrial carcinoma occurs in the epithelial endometrial tissue. It is one of the top three malignant tumors in female reproductive tract, which seriously endangers women's health. Furthermore, the incidence of endometrial carcinoma shows a significant increasing trend in recent years. Mesothelin and KAI1 protein immunoreactivity are detected in different endometrial tissues, especially in the carcinoma tissue with different clinicopathological parameters. The study assesses the correlation between the two factors in endometrial carcinoma. This study will provide a theoretical basis for the pathogenesis and treatment of endometrial carcinoma.Materials and MethodsImmunohistochemical staining (S-P) assay was used to measure the expression of mesothelin and KAI1 protein in each of 12 cases of normal and atypical hyperplasia endometrial tissues and 58 cases of endometrial carcinoma tissue.Results1 The expression of mesothelin:Compared with the normal endometrium group, the expression of mesothelin protein in endometrial carcinoma group was increased significantly (P<0.01). There was a significant difference (P<0.05)in mesothelin level between stageⅠtoⅡ(55%) and stageⅢ(88.9%). The significant difference (P <0.01) was also found in well-differentiated carcinoma group (G1,38.8%) and moderately and poorly differentiated carcinoma group (G2-G3,77.5%). The positive rate of superficial myometrial invasion (≤1/2) and deep myometrial invasion (>1/2) was 42.3% and 84.4%, the positive rate of lymph node metastasis and no lymph node metastasis was 94.4% and 52.5% respectively, the differences in both of the two groups are statistically significant (P<0.01).2 The expression of KAI1:Compared with the normal endometrium group, the expression of KAI1 protein in endometrial carcinoma group was decreased significantly (P<0.01). There was a significant difference (P<0.05)in KAI1 level between stageⅠand stageⅡtoⅢ. The distinguished difference (P<0.01) could be evaluated between well-differentiated carcinoma (G1,83.3%) and moderately and poorly differentiated carcinoma (G2-G3,27.5%), as well as between superficial myometrial invasion (≤1/2,65.4%) and deep myometrial invasion (>1/2,28.1%), equally between lymph node metastasis group (22.5%) and no lymph node metastasis group (55%).3 Correlation analysis:In endometrial carcinoma, the expression of mesothelin has negative correlation with the expression of KAI1 protein:r=-0.367, P<0.01.Conclusions1. Mesothelin and KAI1 play an important role in the occurrence and development of endometrial carcinoma.2. The expression of mesothelin and KAI1 may be both involved in the clinical stage, histologic grade, myometrial invasion and lymph node metastasis of endometrial carcinoma. They also play an important role in the invasion and metastasis of endometrial carcinoma.3. In endometrial carcinoma, the expression of mesothelin protein has negative correlation with the expression of KAI1 protein.