Investigation On Five Zang-Organ-Related Theory Of Hypertension And Medication

Essential Hyertension (EH) refers to a syndrome with characteristics of increased aortic blood pressure, which frequently being complicated by injuries of targeted organs such as brain, heart, kidney and etc,is a common cardiovascular disease as the main thereaten factor to the human health with high disability rate and seaverely decreases the life quality of human being.TCM has a dood effect in the prevention of EH, and has became the focus of modern research. Therefore, reasonable utilization of TCM exert its advantages has important significance.Objective1. Through clinical cases investigation, exploration Five zang-organ-related theory of hypertension and TCM syndrome type distribution.2. Under the guidance of Five zang-organ-related theory, using the TCM treatment of hypertension, observe intervention.Methods1. Prospective investigation and collection of cases hypertension between January 2009 to March 2010 in the second TCM Hospital of Guangdong Province outpatient or in hospital hypertension 200 cases, fill in Questionnaire of hypertension Five zang-organ-related, Analysis of the relevant organs of hypertension symptoms.2. All cases of patient records were selected from the 2nd TCM Hospital of Guangdong Province and TCM Hospital of Zhongshan County fill in cases were collected and analyzed the hypertension TCM syndrome type distribution.3. Collecting 120 cases hypertension patients from second Guangdong hospital outpatient or in hospital between June,2009 to March,2010 30 cases of TCM syndrome differentiation of Qi deficiency and phlegm syndrome with the Compound Qima capsule intervention study,30 cases of TCM dialectical patients of Overabundant Liver-Fire syndrome, with the Pinggan capsule intervention study, Another 60 cases of Qi deficiency and phlegm syndrome and Overabundant Liver-Fire syndrome of 30 patients suffered various as control group, the control group treated by Nifedipine Sustained-release Tablets 20mg Bid and/or Captopril Tablets 12.5mg/25mg Tid;the treatment group treated with fthe same and add the Compound Qima Capsule 2 pill Tid or the Pinggan Capsule 2 pill Tid,and observe the indexes of improvement in clinical symptoms blood pressure controlling condition, four items test of blood lipid and side-effect occurrences.Results1. Hypertension Five zang-organ-related research results show that the essential hypertensive patients with clinical manifestations of heart, liver, spleen, this kind of phenomenon closely "Five zang-organ-related theory" by DengLao in the core idea of spleen center, That hypertension Five zang-organ-related theory exists objectively.2. Hypertension TCM syndrome type distribution survey results:Hypertension four types of TCM syndrome type between age groups has significant differences (P (0.05), and gender has no significant difference (P> 0.05). Hypertension patients with Phlegm stasis syndrome (56.6%) on the most frequent Secondly is Overabundant Liver-Fire syndrome (22.6%). Yin Vacuity Due to Yang Hyperactivity (4.8%) and the other types (15.7).3. The therapeutic efficacy result of Compound Qima Capsule for Qi deficiency and phlegm syndrome of hypertension indicate that therapeutic efficacy on blood pressure of the treatment group is 93.0%and that of the control group is 88.3%, there is statistic difference between them (P (0.05).Corres-ponding to the clinical treatment effect rate with 96.7%in comparison to 93.3%(P (0.05).the treatment group was superior to the control group in reducing TC,TG level and the former could enhance HDL index relating to the therapeutic effect on reducing blood lipid (P (0.01).4. The therapeutic efficacy result of Pinggan Capsule for Qi deficiency and phlegm syndrome of hypertension indicate that therapeutic efficacy on blood pressure of the treatment group is 93.3%and that of the control group is 83.3%, there is statistic difference between them (P (0.05).Corresponding to the clinical treatment effect rate with 96.7%in comparison to 83.3%(P (0.05). the treatment group was superior to the control group in reducing TC,TG level and the former could enhance HDL index relating to the therapeutic effect on reducing blood lipid (P (0.01)Conclusions1. The hypertension Five zang-organ-related theory exists objectively, using this theory to guide clinical treatment of hypertension is exactly curative effect.2. Hypertension TCM syndrome type distribution according to the proportion in order is Phlegm stasis,Overabundant Liver-Fire syndrome,Yin Vacuity Due to Yang Hyperactivity and the other types.3. Compound Qima capsule and Pinggan capsule respective in the treatment of Qi deficiency and phlegm syndrome and h Qi deficiency and phlegm syndrome of hypertension has suffered exactly curative effect, Considering its blood pressure,narrowing pulse blood pressure,cholesterol-lowering,improve symptoms related aspects of the curative effect.