| Background:With the population aging, older adults with knee osteoarthritis incidence continued to rise.100 various types of arthritis, in which cartilage back into the main features of osteoarthritis of the hip is one of the most common type.38-60 years of age in our population,78.5% suffered from osteoarthritis. Beijing Hospital, Ministry of Health has led to the "China in the old state of osteoarthritis, " The results show that the country six regions (Northeast, North, East, South, Southwest, Northwest) people over the age of 40 patients with primary bone and joint diseases rate of 46.3%.Osteoarthritis of the knee more easily than the other diseases affecting elderly patients and walking, stair climbing and other lower limb function. Therefore, osteoarthritis is caused functional disability in the elderly population, resulting in economic losses and affecting social development, one of the major diseases. How to treat knee osteoarthritis, to improve the quality of life of patients, research is effective, safe, high titer of treatment intervention programs, population and health fields is an important issue facing with a wide range of urgent social needs.objective:Through hydrochlor ic ammonia the glucose capsule (portuguese a capsule), provide External application of chinese medicine, acupuncture treatment knees to osteoarthritis of the clinical effectiveness and security is clear evidence that their respective effect of the role of the characteristics of chinese medicine treatment knee to osteoarthr it is normal ization treatment in medical science is based on evidence provided.Methods:A randomized controlled trials of clinical research methods. Subjects based on research objectives and criteria (diagnostic criteria, inclusion criteria and exclusion criteria), will meet the standard Subjects were randomly assigned to oral administration of glucosamine hydrochloride capsule group, external application of Chinese medicine treatment group, acupuncture treatment group. N=30 cases, oral administration of glucosamine hydrochloride capsule group:Each 0.24g,3 times/day, and topical traditional Chinese medicine treatment group:compound Bauhinia extinction Ointment,1 times/day, patching select night, partial knee cleaned Sticking, patching the various parts of the lateral knee select one, patching removed after 12-15 hours; acupuncture treatment group:Every 20 minutes, Acupuncture 2 times a week, intervention schedule for 4 weeks, every 2 weeks visiting a meeting, after a period of observation, and record the three groups before treatment two weeks later, after treatment of the scale results. Removed and falling standards:1, serious adverse events; 2, testing the process of the merger of serious diseases; 3, subjects with poor compliance, failure to carry out treatment in doctor's advice; four patients withdrew from the study on their own; five patients during follow-up lost to follow for various reasons. Comply with any one who removed from the study. The primary efficacy endpoint: patients, respectively, before treatment and after 2 weeks after the end of the use of internationally accepted course of treatment of knee osteoarthritis WOMAC scale. Rating Methods:100mm line at both ends, respectively, "pain" (0mm) recorded as 0 points and the "imaginary pain" (100mm) recorded as 100 points. Measured by the degree according to their feelings, in a straight line to mark the corresponding position, "painless" end-to-mark shall be judged by the distance between the (mm), arrive at the corresponding scores. Evaluation criteria:clinical recovery:the symptoms disappeared and normal functional activity, WOMAC osteoarthritis Total decrease≥95%; markedly: the symptoms disappeared, normal joint function, WOMAC osteoarthritis decreased≥66%; Effective:the pain disappeared, joint range of motion is normal, WOMAC osteoarthritis points decline≥33%; invalid:does not meet the standard of effectiveness or even increase, WOMAC osteoarthritis points decline≤33% or even increase.Results:External application of Chinese medicine group,7 were males and 23 female, mean age 52.3 years, mean duration of 4.6 years, obesity in 8 cases,17 cases of right knee, left knee in 13 cases, before treatment the average WOMAC total score points 614.2±406.96 min, (pain items GPA 131.37±84.878 points, rigid entry GPA 61.90±53.225 points, functional items GPA 420.93±288.87 minutes), acupuncture group,5 male,25 female, mean age 49.6 years, mean duration of 5.7 years obesity in 7 cases,18 cases of right knee, left knee in 12 cases, the average points score before treatment 601.46±314.52 points (pain points in mean 144.27±58.18 points, rigid item average of 33.53±39.61 points, functional items GPA 423.67±237.60 min), Glucosamine group of 6 males and 24 females, average age 51.5 years, mean duration of 6.1 years, obesity in 9 cases,21 cases of right knee, left knee in 9 cases Before the treatment, the average points score 622.23±270.35 points (pain points in mean 129.33±68.94 points, rigid items GPA 24.73±18.319 points, functional items GPA 468.17±203.691 points). The sex ratio of three groups of patients, average age, weight, disease course, treatment points, compared with no significant difference (P & gt; 0.05), after treatment, three groups of symptoms score Decreased significantly 2 weeks after the external application of Chinese medicine group symptom score decreased to 522.07±410.342 points (pain points in mean 103.90±74.054 points, rigid entry GPA 46.83±53.98 points, functional items GPA 371.33±304.973 points), acupuncture group of symptoms Points reduced to 522.07±410.342 points (pain items GPA 88.83±45.05 points, rigid entry GPA 31.07±39.377 points, functional items GPA 316.63±227.031 points), Glucosamine group symptom score decreased to 549.60±249.245 points (pain items average credit 117.70±62.389 points, rigid entry points average of 20.13±16.017 points, Function entry points 411.77±181.148 points on average),4 weeks after the external application of Chinese medicine group symptom score was reduced to 369.2±358.36 points (pain points in mean 83.03±77.802 points, rigid entry GPA 30.73±42.9 points, functional items GPA 255.43±257.009 points), acupuncture group symptom score was reduced to 332.33±258.349 points (pain points in mean 59.23±41.602 points, rigid entry GPA 24.77±36.289 points, functional items GPA 248.33±198.88 min), Glucosamine group symptom score was reduced to 368.30±218.663 points (pain points in mean 72.97±52.906 points, rigid Item average credit 11.33±10.835 points, functional items GPA 284.00±161.925 points), For two weeks after external application of Chinese medicine group of chinese medicine can effectively alleviate (p<0.05), acupuncture therapy groups, two weeks after stiff in alleviating not obvious (p>0.05) the pain of the item and to effectively alleviate (p<0.05), portuguese and a group therapy can be effectively improve (p<0.05), after about three groups to pain and stiffness and functions are effective in improving (p<0.05), three groups, for two weeks later, the stiffness in external application effect of a group of the portuguese effect. acupuncture group effect (p<0.05) in pain, acupuncture groups than the other two groups of the effect of significantly (p<0.05) external application group and may make group obvious differences between the two groups is (p>0.05) in three aspects, there is no obvious differences between (p>0.05). for two weeks after three the total availability of chinese medicine external application group23.3%, acupuncture group 40.0%, may make group 0%, there are significant gender difference in meaning, for four weeks after three the total availability of chinese medicine external application group50.0%, acupuncture group 76.7%, may make group 73.3%,no significant gender difference. three groups of the treatment process is no visible reaction.Conclusion:External application of Chinese medicine, acupuncture and Glucosamine treatment of osteoarthritis of the knee is an effective method of treatment 2 weeks TCM herbs and acupuncture was remarkably superior to the Portuguese legislation, but in between there is no significant difference in the efficiency of the treatment 4 weeks after the treatment no significant difference between the total effective rate in the different stages of disease, In remission, the three groups can effectively alleviate the symptoms, For two weeks after external application of Chinese medicine group of chinese medicine can effectively alleviate (p<0.05) acupuncture therapy groups, two weeks after stiff in alleviating not obvious (p<0.05), the pain of the item and to effectively alleviate (p<0.05), portuguese and a group therapy can be effectively improve (p<0.05), after about three groups to pain and stiffness and functions are effective in improving (p<0.05),Worthy of clinical application. Three groups, for two weeks and four weeks, the stiffness in respect of the portuguese external application of Chinese medicine effect of a group of effective results. acupuncture group (p<0.05) in pain, acupuncture groups than the other two groups of the effect of significantly (p<0.05) external application of Chinese medicine group and may make group obvious differences between the two groups (p>0.05) in three aspects, there is no obvious differences between (p>0.05).
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