Curative Effect And Mechanism Of Wormwood And Scutellaria Gallbladder Clearing Decoction Cured Viral Upper Respiratory Tract Infection

Objective:This research bases on the previous clinical experience, integrates dehygrosis with syndrome differentiation and mediation to cure viral upper respiratory tract infection. By way of prospective clinical research, we make an observation about patients who get viral upper respiratory tract infection and syndrome differentiated as damp heat. We mensurated the serum levels of T-lymphocytes CD3+%,CD4+%,CD8+%,NK%and calculated CD4+/CD8+. Accordingly we may reveal the biochemical basis and mechanism of damp heat syndrome in viral upper respiratory tract infection. Wormwood and Scutellaria Gallbladder Clearing Decoction can clear away heat and expel dampness, we use this decoction to cure the disease in order to prove the formation of substance of damp heat syndrome and guide the diagnosis and treatment of damp heat syndrome in viral upper respiratory tract infection.Methods:We selected 30 patients as case group, which diagnosed as viral upper respiratory tract infection from the medicine clinic and emergency clinic in First Affiliated Hospital of Guangzhou University of Chinese Medicine, GuangZhou Hospital of Integrated Traditional and Western Medicine, GuangDong Hospital of Traditional Chinese Medicine, and 10 normal cases as control group. Case group and control group were native people lived in southern areas in China. According to syndrome differentiation, Indirect immunofluorescence was used to detect the blood serum for T-lymphocyte subset was tested by flow cytometry, Compared the change of immune function and the level of free radical in damp-heat syndrome group,warm-heat syndrome group and control group. Wormwood and Scutellaria Gallbladder Clearing Decoction was used to cure Damp-heat syndrome group for three days, then used the same method to retest the T-lymphocyte subset and the level of free radical, Observed how the pricinple of clearing away heat and expelling dampness worked on damp-heat syndrome.Results:About the change of T-lymphocyte subset, CD3%,CD4% in damp-heat syndrome group was much lower than that of control group (P＜0.05); Compared CD3+%,CD4+%,CD4+／CD8+,NK%, there was no significant difference in two groups(P＞0.05); after damp-heat syndrome group was cured by Wormwood and Scutellaria Gallbladder Clearing Decoction, the level of CD3+%,CD4+%,CD8+%,CD4+／CD8+ were on the trend of increasing, NK% was on the trend of decreasing, but there were no significan difference. (P＞0.05). Conclusion:1. The pathological mechanism of damp-heat syndrome in upper respiratory tract infection has a certain link with immune dysfunction 2. Wormwood and Scutellaria Gallbladder Clearing Decoction has positive effect on damp-heat syndrome of viral upper respiratory tract infection 3. after damp-heat syndrome group was cured by Wormwood and Scutellaria Gallbladder Clearing Decoction, the level of T-lymphocytes were on the trend of increasing, NK% was on the trend of decreasing, but there were no significant difference.