| OjectiveViral upper respiratory tract infection which caused by virus can brings upper respiratory tract inflammation like rhinitis,pharyngitis and tonsillitis to some extent. Common cold,flu,AD viral infection,syncytial viral infection are some common infections in upper respiratory disease, of which the symptom can be mild or serious. At present to cure the disease, there is letter specific medicine, however Chinese Medicine has a larger advantage than western Medicine in preventing and curing the disease. Upper respiratory tract infection belongs to exogenous disease category. It has similar symptom as some diseases in Chinese Medicine: anemogenous febrile disease,acute spring febrile disease,summer febrile disease, taiyang disease, shaoyang disease, yangming disease. In Chinese Medicine some experts hold that most causes of the disease are toxin, most differentiations of syndrome are dampness. Some southern areas like Guangdong and Fujian provinces , which lie in subtropical zone .The weather there is hot and rainy , people have the habit of drinking cool water and eating seafood , exterior and interior pathogenic factors make the spleen and stomach stranded by dampness. In conclusion , patients there get viral upper respiratory tract infection , most of which differentiations of syndrome are damp heat .Modern researches on damp heat indicate that external contraction of pathogenic dampness has direct connection with viral or bacterial infection. There are some index changes in damp heat syndrome : immunological function,free radical,interleukin .Chinese Medicine clearing away heat and expelling dampness can kill pathogenic microorganism directly, two-way regulate the immunological function, reduce free radical damage, help pathological tissue to recover. Patients who get viral upper respiratory tract infection have the same pathological foundation as those who are differentiated as damp heat syndrome. Damp heat pathogen has close connection with viral infection, which offer theoretical,clinical and experimental evidence on relativity between viral upper respiratory tract infection and damp heat syndrome.The condition of environment,immunologic system,metabolism and so many factors have contributed to the formation of damp heat syndrome synthetically. The disorder of digestive tract function,body lipoid and fluid metabolism has constituted as the physiological and pathological foundation of damp heat syndrome. The onste of viral upper respiratory tract infection is closely related to the state of immunologic system. The clinical manifestation and the pathognomonic feature of viral upper respiratory tract infection in southern area extremely resembles weifen and qifen syndrome in theory of seasonal febrile disease, most the differentiations of syndrome include dampness. Our research bases on the previous clinical experience, integrates dehygrosis with syndrome differentiation and mediation to cure viral upper respiratory tract infection. By way of prospective clinical research , we make an observation about patients who get viral upper respiratory tract infection and syndrome differentiated as damp heat. We mensurated the serum levels of T-lymphocytes CD3~+%,CD4~+%,CD8~+%,CD4~+/CD8~+,NK%. Accordingly we may reveal the biochemical basis and mechanism of damp heat syndrome in viral upper respiratory tract infection. Wormwgod and Scutellaria Gallbladder Clearing Decoction can clear away heat and expel dampness, we use this decoction to cure the disease in order to regulat and guide the diagnosis and treatment of damp heat syndrome in viral upper respiratory tract infection.MethodWe selected 60 patients, which diagnosed as viral upper respiratory tract infection from the medicine clinic and emergency clinic in First Affiliated Hospital of Guangzhou University of Chinese Medicine, GuangZhou Hospital of Integrated Traditional and Western Medicine, GuangDong Hospital of Traditional Chinese Medicine. The patients were native people lived in southern areas in China. According to syndrome differentiation, the patients all belonged to the group which was damp-heat syndrome group. T-lymphocyte subset was tested by flow cytometry. Compared the change of immunologicalfunction between the patients and health people. By using single-blinded, randomized controlled method , the patients was devided into two groups, which were case group(30cases) and control group group(30cases). Wormwood and Scutellaria Gallbladder Clearing Decoction was used to cure case group for three days. Ribavirin was used to cure control group for three days. Then used the same method to retest the T-lymphocyte subset in order to observe Wormwood and Scutellaria Gallbladder Clearing Decoction worked on damp-heat syndrome.ResultCD8~+% in case group and control group was much lower than that of the group which was make up with health peopl (P<0. 01); Compared CD~3%,CD~4%,CD4~+/CD8~+,NK%, there was no significant difference in three groups(P>0.05). After case group was cured by Wormwood and Scutellaria Gallbladder Clearing Decoction, CD3~+%,CD4~+%,CD8~+%,CD4~+/CD8~+were on the trend of increasing. There were significant difference (P<0. 05) ;NK% was on the trend of decreasing, but there were no significant difference. (P>0. 05). After control group was cured by Wormwood and Scutellaria Gallbladder Clearing Decoction, CD3~+%,CD4~+%,CD8~+%,CD4~+/CD8~+,NK% were on the trend of increasing, and there were no significant difference(P>0.05). It point out that Wormwood and Scutellaria Gallbladder Clearing Decoction can mprove cellular immunity and humoral immunity of the body.Conclusion1. Compare with Ribavirin, Wormwood and Scutellaria Gallbladder Clearing Decoction can obviously reduce the disease symptom of viral upper respiratory tract infection with type of damp-heat. It is safe to the body. And no adverse reactions happened to the body.2. The pathological mechanism of damp-heat syndrome in upper respiratory tract infection has a certain link with immune dysfunction, and this abnormal mechanism may induce the imbalance between yin and yang and the lingering and refractory pathological changes in damp-heat syndrome.3. Wormwood and Scutellaria Gallbladder Clearing Decoction can regulate immunological function in patients with viral upper respiratory tract infection with type of damp-heat.
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