Therapeutic Effect And Experimental Study Of Haoqin Qingdan Decoction For Lingnan Upper Respiratory Tract Virus Infection With Damp-heat Syndrome

Background:In view of respiratory virus infection of the high incidence of clinical disease,causes more complicated in recent years,a variety of trends,only symptomatic treatment is currently in support of Western-based treatment,despite broad-spectrum anti-viral agents,but So far,no treatment and prevention of influenza and other viral infections drug cure.At present,Haoqin Qingdan Decoction confirmed by the experimental study of Chinese medicine to overcome the abuse of antibiotic resistance arising,dysbacteriosis,all kinds of defects and other side effects.Haoqin Qingdan Decoction of research highlights the soup to the new with the ancient,traditional medicine has played a Doctrine of Epidemic Febrile Disease in the anti-viral,antibacterial, antitoxic,immune modulation,gastrointestinal regulation,antipyretic and other advantages,the external sense of acute fever treatment opens up a new way.Therefore we have established on this subject,is intended to Exogenous Febrile Disease in Chinese medicine for the Doctrine of Epidemic Febrile Disease entry point to a large number of clinical observation as a primary means,by observing the prescriptions of traditional Chinese medicine soup Haoqin Qingdan treatment of upper respiratory tract infection Damp-heat,as well as the clinical efficacy Detection of immune-related indicators to explore the soup Haoqin Qingdan the advantages of the treatment of this disease and its impact on immune function.To play a traditional Chinese medicine for the overall governance of the dialectic of the advantages of anti-viral medicine to guide clinical drug research and Differential Treatment of the Legislative Group to provide a scientific basis.MethodsDamp-heat and western medicine group were the control group during the same period of the Lingnan area resident,was diagnosed with upper respiratory tract infection patients,a total of 57 cases,in order to come from the Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital of Integrated Traditional and Western Medicine Hospital,Guangzhou,Guangdong Province Chinese medicine hospital outpatient and emergency patients.TCM are exopathie by Damp-heat total oF 37 cases for the heat group,western medicine in patients with the control group a total of 20 eases.Another 20 cases of normal control group, healthy people for the same period.Flow cytometry using two sets of peripheral blood T-lymphocyte subsets CD3~+%,CD4~+%,CD8~+%,and NK%scale. One group of patients with Damp-heat Haoqin Qingdan Decoction given mixture,the control group of western medicine to intervene in the treatment of ribavirin given 3 days later,the same method with the above-mentioned indicators retest in order to observe the role of the intervention.And compare the two groups of patients with symptoms before and after treatment to observe changes the efficacy of the role and characteristics,such as fever.resultsThe virus antibody(IgM) positive rate between Damp-heat and western medicine group were no significant difference(P＞0.05),and compared the two groups in the four viruses(influenza A,influenza B,adenovirus, syncytial virus) antibody detection rate,the results showed that two groups of virus antibody detection rate were no significant differences (P＞0.05).In immune function,compared with the the normal group,CD8~+% of Damp-heat group lower with significant difference(P＜0.05);compared with the western medicine group,NK%of Damp-heat group increase with significant difference(P＜0.05);compared with the western medicine group and the normal group,exogenous heat group CD3 +%,CD4 +%,CD8 +% there was a downward trend,but the change was no significant difference (P>0.05);Damp-heat group before and after the treatment,CD3~+%,CD4%, CD8~+%than that before treatment there was an upward trend,NK%than that before treatment there was a downward trend,However,no significant difference(P>0.05).Efficacy in the disease,the Damp-heat group efficiency of the total 95%,western medicine group 85%of the total effective rate,the two groups significantly different effect(P <0.05); in alleviating symptoms of fever and antipyretic effect on the average amount of time,the Damp-heat group better than the western medicine group, significant differences(P<0.05).Conclusion1.Haoqin Qingdan Decoction in the treatment of upper respiratory tract virus infections significant effect,with rapid onset,short time the body temperature returned to normal,ease the symptoms significant, as well as the symptoms of the legacy.2.Upper respiratory tract virus infection with Damp-heat syndrome may permit the existence of immune function,and Haoqin Qingdan possible regulation the immune function.