Clinical Analysis Of Hospital Systemic Fungal Infection In ICU

Intensive care unit (ICU) is the center for variety of critically ill patients, is equipped with advanced medical equipment and experienced medical staff, surporting treatment of critically ill patients with a favorable conditions, But, because of their older patients, severe illness, long hospital stay, bed for a long time, coupled with the development of medicine, invasive operation gradually increased, the broad application of spectrum antibiotics and other factors all contribute to fungal infection becoming an important part of nosocomial infection, the incidence increased year by year, drug-resistant strains emerging, and in case of deep fungal infection, resulted in high cost and poor prognosis, the clinical diagnosis of fungal infections is extremely difficult,so grasping the trend of common pathogenic bacteria and bacteria, controlling risk factors, and the timely implementation of preventive treatment, getting the incidence of fungal infection to a minimum is of important clinical significance,In this study, I pay a lot of intention on this issue.In this paper, I summarized pathogens detected in the patient samples of patients in intensive care unit of our hospital from January 2007 to December 2009 ,and analysis the statistical. I have removed the pollution and repeated detection of strains of the same patient. Fungal culture in accordance with conventional methods.Results: 1. The rate of infection was increasing in the 3 years, deep fungal infection has become a serious problem of hospital acquired infection. 2. fungal infection risk factors: mostly to elderly patients, up to 67.74% in elderly patients with physical weakened immune function, accompanied by severe underlying diseases, patients with heavier, longer hospital stay, lower immunity, poor nutrition state, long-term repeated using of broad spectrum antibiotics and corticosteroids, as well as invasive operation increasing, such as: deep venous catheter, long-term indwelling catheter, indwelling drainage tubes invasive treatment measures adding the risk of infection.。3. The fungi Candida albicans isolated rate is the highest, accounting for 49.03% (101/206), followed by Candida glabrata accounts for 24.27% (50/206), basically consistent with the literature. However, Candida glabrata, Candida krusei and other non-Candida albicans possess a increasing proportion year by year. 4. Infection mainly occur in the respiratory tract and digestive tract, which accounted for 80.1% of respiratory tract, gastrointestinal tract accounted for 6.31%. The reason for higher proportion of respiratory tract is the large proportion of patients with respiratory failure, higher rate of sputum specimens submitted for censorship, fungal colonization was more than the other parts, high false positive rate of sputum culture also related. 5. On the serological examination of fungal infection, molecular biology and pathological biopsy examination is lacking in this study also the shortcomings of this study, with the fungal infection in clinical work becoming more and more important shortcomings will be made up by the future work.Conclusion: 1. ICU incidence of fungal infections increased year by year. 2. Aging, underlying disease, invasive operation and application of weight spectrum antibiotics are the risk factors for fungal infection. 3. Candida albicans is still the main species, but the proportion of non-Candida albicans is increasing year by year. 4. ICU diagnosis of fungal infection is extremely difficult, prevention is so important.