The Clinical Significance Of Plasma Neuropeptide Y And Endothelin Level In Patients With Actue Cerebral Infarction

Objective:To observe the changes of neuropeptide Y (neuropeptideY, NPY) and endothelin (endothelin, ET) in Patients with acute cerebral infarction To study the correlation and neurological deficits between NPY and ET.,and to further explore the role of acute cerebral infarction and its possible pathophysiology.Methods:Patients with acute cerebral infarction group for 30 cases; 27cases of healthy control group, in terms of age, gender composition comparable (P>0.05). in line with the income group of standards. Radioimmunoassay method was used to detect the two groups of NPY and ET levels, And to observe NPY and ET levels within 48 hours of onset and the first 10 days after admission in patients with acute cerebral infarction. Of patients with acute cerebral infarction in patients with neurological deficits of the extent of the use of U.S. National Institutes of Health Stroke Scale (NIHSS) assessed. Admission within 48 h and 10d of each assessment were recorded as NIHSS1, NIHSS2. Assessment 1 The results of the use of statistical software SPSS 10.0 statistical processing, CI group and control group sample was used to analyze the differences between the two independent samples t test;cerebral NPY, ET levels Analysis using paired t test; bivariate correlation between the single-factor analysis of the use of linear correlation analysis, a test of the standard test for bilateral (P<0.05).Results:1.Pathogenesis of cerebral infarction within 48 hours and 10th days of NPY level compared with the control group there was no significant difference;pathogenesis of cerebral infarction within 48 hours of ET level was higher than the control group,th10th days of ET level was significantly higher than the control group, with significant difference (P<0.05).2.Pathogenesis of cerebral infarction within 48 hours and 10th days of NPY level and ET level compared with NIHSS score and change in NIHSS score there was no significant difference.3. Pathogenesis in patients with cerebral infarction within48 hours and 10th day of NPY level has no correlation between ET level.Within 48 hours and 10th day of NPY Level difference and the level of ET Level difference and 10th days of ET level was a negative correlation(P<0.05).Conclusions:1. the incidence of plasma NPY levels within 48h and the plasma ET levels were significantly higher than the control group, with significant differences, suggesting that ET levels may affect the recovery of neurological function in patients with cerebral infarction.compared with the control group decreased, plasma NPY levels during the first 10th day further reduced, but not statistically significant. NPY levels in patients with cerebral infarction prompted changes may be affected course.The present study to detect the level of selecting the first 10th day NPY, failed to detect further recovery, NPY levels in patients with cerebral infarction changes need to be further study in clinical. Article 10th day of plasma ET level was significantly higher than the control group, suggesting that the level of acute cerebral infarction ET development.2.Pathogenesis of cerebral infarction within 48 hours and 10th days of NPY level and ET level compared with the severity there was no significant difference.3. Pathogenesis in patients with cerebral infarction within48 hours and 10th day of NPY level has no correlation between ET level.Within 48 hours and 10th day of NPY Level difference and the level of ET Level difference and 10th days of ET level was a negative correlation.