Effects Of Acours Gramineus Soland On Anti-hypoxia And Preliminary Mechanism In Mice

[Objective] To investigate effects and its biochemical mechanism of Acorus gramineus soland on anti-hypoxia in mice.[Methods] Forty mice were randomly divided into four groups, control group, Acorus gramineus soland low dose group (1.23g/kg),middle dose group (2.46g/kg) and large dose group (4.92g/kg). It is ten in each group. The control group was administrated by physiological saline. The anti-hypoxia time was measured after intragastric administration three weeks. The blood was obtained by stabing heart in mice. Superoxide dismutase activity and malondialdehyde content were determined by centrifuging the blood.[Results] 1. Effects of Acorus gramineus soland on common condition and weight in mice:After intragastric administration three weeks with Acorus gramineus soland in mice, the common contion were good. Moreover, all Acorus gramineus soland groups's mice weight hadn't significantly changed compaired with control group (P>0.05).2. Effects of Acorus gramineus soland on anti-hypoxia time:Acorus gramineus soland with middle dose and large dose could increase anti-hypoxia time compared with control group in mice (P<0.05), but not in low dose group (P>0.05).3. Effects of Acorus gramineus soland on SOD and MDA:Acorus gramineus soland with middle dose and large dose could increase SOD and degrade MDA compaired with control group (P<0.05), but not in low dose group (P>0.05).[Conclusion] Acorus gramineus soland could enhance the ability of anti-hypoxia in mice. Its mechanism of action maybe concerned with enhancing anti-free radical in blood serum.