| According to WHO statistics, cardiovascular diseases kill tens of millions of lives each year, while coronary heart disease is one of the major causes of death. Coronary heart diseases called coronary atherosclerotic heart disease (CHD), the coronary heart disease morbidity Rise 4%-7% above 40-year-old in current chinese. Compared with the developed countrys, such as Europe and America, which slow down to some extent because of taking precautions and union taking precautions against and treating, The method taking precautions against as well as combining prevention with control is to reduce coronary heart disease harmfulness main part having effect, so study for its treatment is still hot topics of common interest at home and abroad.In Traditional Chinese Medicine there is no "Coronary Heart Disease" Illness, coronary heart disease is Chest pain in Chinese, The name of Chest pain starts with "Yellow Emperor", Most of coronary heart disease result from coronary insufficiency due to the myocardial ischemia and hypoxia. shortness of breath with heart palpitations, precordial discomfort as the main performance. Clinical observation, it will aggravate because of cold and pain reduction because of warm even without signs of Deficiency. So that the heart failure Yang Qi is the basis of coronary heart disease. TCM theory holds that one main function of the heart is dominating the blood, but clinical research by physicians found that the most important function of heart is the main heart yang, followed by the main blood vessels. If the heart function and the Yang Qi are low, together with other risk factors will lead to blood stasis, the poor running of the blood will lead to sickness.Thus, the basis of the deficiency of Qi, combined with the pathological changes such as phlegm, deficiency of yin and obstruction of qi, then shall appear such diseases, but the cause of its appearance is still blood stasis.The experts of Traditional Chinese Medicine of the First Clinic Hospital of Jilin University developed NXKKFY according to TCM syndrome differentiation of coronary heart disease, the pathophysiology of modern medicine, molecular biology and many other point of view, through long-term clinical practice. NXKKFY is come from Bu Yang Huan Wu Tang that is one of the Qing Dynasty Wang Qing Ren's prescriptions.Which compose by Astragalus, Angelica tail, red peony root, peach kernel, safflower, Chuan Xiong, pberetima. We reject the peach kernel, safflower, and peony, adding Night Kodo, Millettla, Radix, Achyranthes, parasitic, Shenjin grass, Notopterygium that is NXKKFY, both retain their effectiveness,also increase the protection to the heart and kidney. Astragalus as the monarch drug in this prescription and its dosage is more than others, which can inprove the function of the spleen and stomach, so that the Qi can accelerate the blood circulation, blood stasis disappears. Danggui is the minister medicine that is good for blood, and there is the magical effect to blood stasis without injury. On this basis, by Night Kodo to nourishing the nerves.The functions of Achyranthes and Polygonum multiflorum are nourishing the liver and kidney, add Notopterygium, Shenjin grass to enhance the functions of relaxing the muscles and stimulating the blood circulation. The Prescription include a large number of drugs of tonifying Qi and lifting yang with a small amount of drugs of relaxing the muscles and stimulating the blood circulation, so improve the blood gas without injury. In recent years, Bu Yang Huan Wu Tang is widely used in clinical with drug research, pharmacological studies suggest that it can anti-lipid peroxidation, dilite the blood vessels, improve circulation, reduce platelet aggregation, anti-inflammatory, to protect the role of vascular endothelial cell. On the basis of studying, NXKKFY will have more effect to the patients of coronary heart disease.As the drug is compound, and its effective mechanism is multifaceted, and we only from the perspective of several factors for this preliminary experimental study. The experiments are intended to qi deficiency blood stasis rat model with coronary heart disease, from NO, ET, Hcy to explore the factors related to treatment mechanism on coronary heart disease, so as to provide evidence for Chinese medicine treatment of coronary heart disease and further experimental research.Of 48 healthy adult Wistar rats were randomly divided into 6 groups, give the normal diet 7 days, after that regular feeding the different doses of NXKKFY and the Compound Danshen Dripping Pills 20 days. Then the rats were given ISO injection twice and the heart monitor to negative control group,until myocardial ischemia could mark the successful model of replication, After the last injection of ISO, with 10% chloral hydrate anesthetized rats, then open the abdominal cavity, serum made from the abdominal aorta blood about 5ml. Clipping the same parts for myocardial biopsy, and finally observed the pathological changes under the light microscope and photographed.The results show that: Compared with model group, NXKKFY can be in different levels of each group by improving serum NO content, while reducing the serum ET, Hcy levels and the changes of cardiac morphology. Large and medium dose of NXKKFY group and control group are basic integrity of cardiac morphology, myocardial texture clear, and less infiltration of inflame- matory cells than the negative control group.In summary: The study of rats as in the successful replication model of myocardial ischemia, the observation of serum NO, ET, Hcy levels and the changes of myocardial cell morphology, indicating that NXKKFY on myocar- dial ischemia has a clear preventive effect, get by protection of endothelial cells and slow down atherosclerosis.
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