The Study Of Improvement Effect And Mechanism Of NXKKFY On Myocardial Fibrosis In Rats

Myocardial fibrosis (MF) refers to a variety of pathogenic factors (such as inflammation, ischemia, hypoxia, etc.) under normal cardiac structure out of proportion to the increase of collagen fibers, causing collagen concentration increased significantly One typeâ… andâ…¢collagen composed mainly of collagen fiber network, directly affect the myocardial contractile and diastolic function and the, integrity of myocardial tissue morphology, which leads to increased myocardial stiffness. MF has a higher morbidity and mortality. Has become a common disease poses a serious threat to human health. So to find or develop effective prevention or reversal of fibrosis drugs on human health is of great significance. Professor, I am guided by the theory in Chinese medicine, combined with years of experience in clinical practice developed brain heart clinically proven oral liquid BNI, Huayu Tongluo effect. On clinical symptoms and signs of significant improvement in function, effect of the ideal.In this study, rats were divided into 6 groups, 10 rats were the control group, Iso group (myocardial fibrosis model group), Cap group (captopril group), brain heart health oral liquid high, low-dose group. Rats with continuous high-dose intraperitoneal injection of isoproterenol on myocardial fibrosis model rats were prepared, and for the first 10 days to do cardiac pathological morphology in myocardial fibrosis models were successfully established after the execution of large rats, abdominal aortic blood, centrifugation supernatant, test Hyp, H₂O₂ content and GSH-PX, CAT, LDH, CK activity. End of the day myocardial myocardial fibrosis. The results showed that: Iso group HE staining of myocardial fibers Department endocardial fibrous hyperplasia, lamellar distribution of myocardial vascular congestion and a small amount of expansion of inflammatory cell infiltration, the model was successful. The NXKKFY each dose group had different changes in myocardial fibrosis, myocardial fibrosis Iso group than light, that could reduce the dose NXKKFY the content of collagen. Difference between the high dose group which NXKKFY most significant difference (P <0.01) compared with the Cap was no significant difference (P> 0.05). In Hyp, LDH, CK study area, NXKKFY each dose group Hyp, LDH, CK levels are reduced, which NXKKFY most obvious effect of high dose group (P <0.01), and the Cap group was no significant difference (P> 0.05 ). Histopathological observation showed that: myocardial fibrosis in the myocardium of myocardial collagen proliferated, and NXKKFY dose can improve the proliferation of collagen, which is most evident in high dose group. In this study, oral liquid by observing the brain center for the process of serum creatine kinase myocardial ischemia, myocardial collagen and histopathological effects in three areas, together confirm the drug for myocardial fibrosis in rats with improvementMyocardial fibrosis, through various channels produce large amounts of free radicals, while the body defensive system of enzymatic destruction, leading to excessive free radicals in the body. Oxygen free radicals may be the body of the GSH-PX, CAT catalytic removal over removal capacity, oxygen free radicals enhanced oxidation of hydrogen peroxide (H₂O₂), then hydrogen peroxide within the myocardium will be the main GSH-PX , CAT removed. During myocardial ischemia, oxygen free radicals produced within a short time can greatly exceed the removal capacity of SOD, while the generation of large amounts of H₂O₂, consume a large amount of GSH-PX, CAT, serum GSH-PX, CAT activity was significantly lower body H₂O₂ Damage increased. This study showed that myocardial fibrosis, serum H₂O₂ content increased, GSH-PX, CAT activity decreased, serious injury of myocardial cells. The NXKKFY each dose group can effectively increase GSH-PX, CAT activity decreased H₂O₂ content, which NXKKFY high and middle dose group was most effective P <0.01, with no significant difference between Cap group (P> 0.05). NXKKFY can enhance the GSH-PX, CAT activity and reduction of H₂O₂ on myocardial cell injuryMF can be attributed to Chinese medicine"heart palpitations "," heart paralysis "," Asthma "," edema "and other areas. And that the MF main pathogenesis of the development is the main machine for heart vessel disease Blockage of disease and location in mind, the disease and lung, liver, spleen, kidney related., false is mixed, the vacuity, qi deficiency, yang deficiency, yin deficiency, blood deficiency-based, blood stasis, qi stagnation, cold coagulation, phlegm as standard. clinically often to false is mixed, the most common deficiency and blood stasis. treatment to Qi, activating blood circulation, mainly through contact, tackling the problem. NXKKFY famous doctor in Qing Ren Wang created by any of the basis of addition and subtraction BHD come. modern pharmacology study, many of the prescription medicine on the role of myocardial fibrosis with intervention, can improve the lower Hyp, H₂O₂ LDH, CK levels and increase GSH-PX, CAT activity. have reduced myocardial collagen formation, oxidative damage, protect the myocardial cell function effectIn summary, we can get through this experiment the following conclusions: NXKKFY reduced collagen concentration, the protection of cell membrane lipid oxidative damage of membrane damage, reduced myocardial enzyme leakage; and can significantly improve myocardial fibrosis; and NXKKFY also has protection of the structure of cardiac muscle cell function. From the above three confirmed brain heart health oral liquid on experimental myocardial ischemia with a clear protective effect.