| Pregnancy-induced hypertension (HDCP) is a pregnancy-specific diseases, but also common diseases during pregnancy.The incidence rate is 9.4%~ 10.4% in China while in other countries it is 7% ~ 12%. The disease can cause different damage to both mother and her fetus even endanger their lives. It is one of the key reasons for the maternal and perinatal morbidity and mortality. The etiology and pathogenesis of the disease has not been well known which maybe related to immunization, genetic factors, placental ischemia and hypoxia, oxidative stress and other more factors. Now it is widely recognized that the incidence of HDCP is the contribution of many factors which interacted, interrelated, and ultimately induce the occurrence of HDCP. The method to minimize the threatening to mother and fetus has caused close attention of perinatal medical profession. Properia perinatal care and health education can be effective in preventing HDCP and its complications.Regular prenatal care and timely treatment can also prevent progression of the disease, and have great significance to ensure the safe of maternal and fetal.In this study we screened the risk factors for this disease with consulting the related factors included in the epidemiological investigation and the possible risk factors newly reported and considering Chinese specific conditions. We hope that we can provide some basis for the prevention and treatment for this disease.Objective: Analysis the related factors for HDCP by epidemiological survey in order to provide a scientific basis for effective prevention of HDCP.Methods: We choose 110 patients diagnosed HDCP based on history, clinical manifestations and laboratory examinations ,from December,2008 to September,2009 in first hospitl of Jilin University.And in the control group we choose 111 cases diagnosed HDCP and do not have related risk factors during the same period.We take the form of questionnaires. Topics include: general condition, lifestyle, health and disease status, physical examination, serological indicators and so on . Data Entry used EpiData 3.0 software by two people. Data analysis used SPSS 13.0 software. The constitutes ratio of related factors in two groups was analysised byχ2 test. Results:①we have 110 cases of patients in the study group, age ranged from 19 to 41 years old, with an average age of 29.03±6.04 years. A total of 111 cases in control group patients, age range from 19 to 44 years with an average age of 28.67±5.23 years. proportion of≥35-year-old group and < 22-year-old group in study group is greater than the control group, while 22 to 29 age group is less than the control group. In occupational composition, the study group have a higher proportion of farmers, about 61.8%, while the percentage of farmers in the control group is 40.5%. In accordance with the education,the percentage of elementary school and below is accounted for 75.5%, while the control group was only 52.3%; the composition of junior and senior education is correspondent ; college or university and above accounted for only 13.6% in study group and in control group it accounted for 35.1%. In the study group low income patients accounted for 40.0% but in the control group only 20.7% and the general composition in this two different groups is 23.6% and 17.1% respectively while in the high income group it is 36.4% in study group and 62.2% in the control group.In the study group only 24.5% patients did system checks while it is higher in the control group:56.8%.Study group and control groups in pregnancy times play a considerable proportion . However, the study group primipara and pluripara proportion were 60% and 40%, while in the control group the two proportions were 72.7% and 27.3% respectively.In the study group the proportion of obese group was higher than that of control group :30.6% to 18.3%, while the thin group and normal group, the respective proportions were 9.3% and 60.2%, lower than that of the control group :18.3% and 63.3%.Compare with the control group in the study group occupation, education level, economic status, educational level, parity, and BMI differences were statistically significant (p <0.05), while age, pregnant times, pregnancy weight gain, post-pregnancy exercise, pregnancy reaction and family history had no statistically significant difference (p> 0.05).②in study group patients added folic acid, vitamins and calcium were less than control group, compared with the two, the difference was statistically significant (p <0.01).③patients with serum trace elements test, in the study group and control group, calcium content was significantly different (p <0.01), zinc, magnesium, iron and copper content have no statistically significant difference (p> 0.05). in study and control groups of serum elements of lead and cadmium, were normal.④in study group and control group, with the exception of urine protein content was statistically significant different (p <0.01), glucose, albumin, hemoglobin and platelet levels was no significant difference (p> 0.05).⑤food taste, fresh fruit, vegetables and often eat meat, shrimp and beans and milk are significantly different between the study group and control group (p <0.05), the remaining have no statistically significant difference (p> 0.05).⑥smoking was significant different between the two group (p <0.05); a few others have no statistically significant difference p> 0.05.⑦pregnant times, pregnancy weight gain, post-pregnancy exercise, pregnancy reaction and family history have no significant difference. Conclusion: 1. Occupation, economic situation, level of education is factors of pregnancy-induced hypertension disease.2. Body mass index, parity (primipara or maternal), the systemic prenatal checkups and pregnancy-induced hypertension have relationship.3. Age, pregnancy weight gain, the exercise after pregnancy, the degree of response , level of blood pressure during pregnancy and high blood pressure family history have no significant correlations with pregnancy induced hypertension.4. Calcium supplementation during pregnancy, folic acid and vitamin and other nutrients can reduce the incidence of hypertensive disorders in pregnancy.5. Pregnancy-induced hypertension patients have lower calcium serum levels than the control group, while they have slightly higher iron serum levels. Serum zinc, magnesium and copper content have no significant difference.6. Pregnancy-induced hypertension in patients with urinary protein level was significantly higher, while glucose, albumin, hemoglobin and platelet levels were not significantly different.7. Correct habits such as regularly eat fresh fruits, vegetables, meat, fish, dry beans and milk can reduce the incidence of pregnancy-induced hypertension.8. Incorrect habits such as smoking can induce the occurrence of hypertensive disorders in pregnancy. And passive smoking, alcohol consumption and the use of microwave ovens and other lifestyle have no significant correlation with the incidence of pregnancy-induced hypertension.
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