The Express And Significance Of Carbonic Anhydrase Ⅸ In Bladder Transitional Cell Carcinoma

Objective:The Express and Significance of Carbonic AnhydraseⅨin Bladder Transitional Cell Carcinoma.Method:60 cases of bladder transitional cell carcinoma tissue were taken from the patients undergone lobotomy of bladder because of bladder cancer in Xiang Ya 2 hospital between 2004 and 2008,including various histopathological grading and clinical stage.And 10 cases of normal bladder epithelial tissue.Immunohistochemical staining(S-P method)for CAIX in bladder cancer was performed and analyzed by statistics.Results:In bladder transitional cell carcinoma tissues,the expression of CAIX was identified in 47cases(78.33%),but in the normal bladder epithelial tissue,the expression of CAIX was negative (P＜0.01).The expression of CAIX was significantly associated with the clinical stage,pathology grade,Size,tumor recurrence(p＜0.05),it is not correlated with the number of tumor,age and gender of patient.(p＜0.05).Conclusion:①In bladder transitional cell carcinoma tissues,the expression of CAIX was high,but in the normal bladder epithelial tissue, the expression of CAIX was negative.②There was significant correlation between the expression of CAIX and clinical stage,pathology grade,size,tumor recurrence,but it is not correlated with the number of tumor,age and gender of patient.③As CAIX is highly expressed in bladder transitional cell carcinoma,but not in normal urothelial tissue,it represents a potential cancer-specific therapeutic target.There may be a role as an intravesical-targeted agent for instillation therapy.Baseline immunohistochemical staining of CAIX expression levels could be used to select patients and to determine whether the tumour can be targeted appropriately with a CAIX-directed approach.