Study On Effect Of Cranial Sutures Acupuncture Plus Drugs On Neural Function Rehabilitation And Dynamic Change Of Serum S100B In The Patients Of Acute Cerebral Infarction

Objective:To explore neural function rehabilitation and dynamic change of serum S100B protein with cranial sutures acupuncture combined with drugs for treatment of acute cerebral infarction (CI).Methods: According to the clinical diagnostic criterion of the cerebrovascular disease in the fourth national academic discussion of cerebrovascular disease in Chengdu in 1994,49 patients,ranging from 45 to 75 years in age , were enrolled, male 29 and female 20, 40 patients were completed the study.All patients were randomly divided into a medication group(A group) of 20 cases and a needling cranial sutures plus medication group(B group) of 20 cases, the patients of A group was taken treatment measures ,such as conrolling brain edema,reducing blood pressure and nourishing nerve,etc.In B group, besides the same treatment measures as A group,needling cranial sutures was performed from the second day of following onset,once daily,8 times constituting one course.In addition, 20 healthy subjects between age 45 and 75 were served as a control group(C group) of normal concentration of serum S100B.The observation time was from the second to tenth days, the scores of neural function defect, dynamic change of serum S100B and their correlation were compared.Results:(1)In A group,the scores of neural function defect didn't improved significantly between the second and forth day(P>0.05), with very significant difference between the forth (or second) and tenth day respcetively(P<0.01).(2)There were no significant difference in the scores of neural function defect between the second and forth day in B group respectively(P>0.05); There were very significant difference in the scores of neural function defect between the second,forth and tenth day in B group respectively(P<0.01).(3) In both A and B group, with no significant difference in the scores of neural function defect of the second or forth day (P>0.05),there was a significant difference in the scores of neural function defect of the tenth day (P<0.05).(4)The contents of serum S100B in the patients of acute cerebral infarction in both A and B group was obviously higher than that of the normal control group, after onset of the rapid increase in the concentration of serum S100B, decreased gradually after the peak arrival. In both A and B group, with no significant difference in the contents of S100B of the second or forth day,there was a significant difference in defect of the tenth day. the contents of S100B in B group decreased faster than that in A group. (5)There were very significant difference in the contents of serum S100B between the second,forth and tenth day in A or B group respectively(P<0.01).(6)The contents of S100B of the second,forth or tenth day in A or B group decreased significantly as separately compared with the normal control group(P<0.01).(7)The scores of neural function defect was no significantly correlatedwith the concentration of serum S100B in acte stage before and after treatment.Conclusions:(1) Both medication and cranial sutures plus medication for treatment of acute cerebral infarction can improve neural function,but clinical therapeutic effect of the latter is significantly supperior to that of the former. (2)The contents of serum S100B in the patients of acute cerebral infarction is significantly higher than that of normal serum S100B,it is suggested that serum s100b is in the process of dynamic change, cranial sutures plus medication group of concentration of serum S100B decreased faster than the medication group .(3)needling cranial sutures can accelerately promote the descent of serum concentration of S100B and better to improve neural function in the patients of the acute stage cerebral infarction.