Relationship Between Alzheimer's Disease And Vascular Factors

bjective: Alzheimer's disease (Alzheimer's disease, AD) is a serious disease. According to incomplete statistics about the world's 500 million people beset by the disease. when patients with advanced disease more than the loss of social activitie, psychiatric symptoms, initiative reduced, paranoid and eccentric behavior or ignored into the symptoms of bulimia and muscle cramps, urinary incontinence, mutism even staied in bed. Typical symptoms were sustained after 5-10 years.Patients often die of malnutrition, pulmonary complications such as infections, pressure ulcers. Its resulted in serious economic and social burden. In the traditional view, AD is a disease of older, with genetic, viral infection, inflammation, aluminumpoisoning, cholinergic system dysfunction, cytoskeletal changes and brain trauma.Vascular factors were not mentioned. AD and vascular dementia (vascular dementia, VaD) completely into the concept of degeneration and vascular disease. whether or not cerebrovascular disease is any distinction between AD and VaD as the main points[3]. In recent years, with the constant depth of the research about AD, it found that angiogenic factors in the occurrence of and development AD plays an important role[1-2]. It have evidenced in epidemiology,neuropathology, ne- uroimaging, neuroscience Molecular Biology research fields of study.AD is not a simple disease. The pathological damage and coexistence of vascu- lar injury and the joint role in promoting the progress of AD pathogenesis [4]. In this paper, it was our hope to carry out a further study to examine the AD with cerebrovascular disease and the relationship between risk factors. Methods: A case-control study including 40 cognitive normal controls and 53 possible AD patients in Chinese Sichuan People's Hospital was conduc- ted.The patients and controls were matched for gender,occupation and education level.It analysised the two cases of high blood pressure, diabetes, abnormal lipid metabolism, cerebral infarction, neck vessel stenosis and plaque, intimal thickening of the neck, intracranial blood flow slowed dow- n, smoking, drinking the distribution of liquor.The relationship between AD and vascular factors was analyzed by Logistic model. The level of statistical significance of differences in multivariate analysis was P<0.05. Results: Hypertension, diabetes, abnormal lipid metabolism, cerebral infa- rcttion, neck vessels'stenosis and plaque, intimal thickening of the neck v- essels, anterior cerebral artery, middle, cerebral artery, posterior cerebral artery's blood flow slowed down in between the AD and the control group significantly difference (P<0.05).smoking,drinking in between AD and co- ntrol groups were not significantly different (P> 0.05). Conclusion: AD is associated to vascular factors. High blood pressure, diabetes, abnormal lipid metabolism, cerebral infarction, neck vessels stenosis and plaque, intimal thickening of the neck vessels, intracranial blood flow velocity is slowed down the independence of the risk of AD factors.