Correlation Analysis Of The Relationship Between Cognitive Function,activities Of Daily Living And Serum Inflammatory Factors In Patients With Alzheimer's Disease

Objective: To explore the relationship between serum inflammatory cytokines and clinical cognitive function and activities of daily living in patients with Alzheimer' s disease,AD),so as to provide a possible new biological index for the clinical diagnosis of AD,and provide a scientific basis for the later study of new therapeutic targets of AD.Methods: 30 patients with AD and 30 NC were included in the study.The Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(Mo CA),Alzheimer's Disease Assessment Scale-cognitive(ADAS-cog),The Activity of Daily Living(ADL),Hachinski Ischemia Scale(HIS)and Geriatric Depression Scale(GDS)were used to evaluate participants of the AD and NC.The levels of serum inflammatory factors in patients with AD and NC were detected by ELISA technology,and the levels of serum inflammatory factors in AD group and NC group were compared,and the correlation between serum inflammatory factors and cognitive function and activities of daily living in AD group was analyzed.Results:1.The serum levels of IL-2,IL-6,IL-10,TNF-? and IL-17 A in AD group were significantly higher than those in the healthy control group(P < 0.05).The level of serum IL-6 was significantly correlated with age,course of disease and years of education(r=0.369,P=0.045,r=0.368,P=0.045;r=-0.397,P=0.030),and IL-10 was significantly correlated with the course of disease(r = 0.380,P =0.039).2?In AD group,there was a significant correlation between the score of MMSE,Mo CA,ADAS-cog and the level of serum IL-17 A factor(r=0.364,P=0.048;r=0.375,P=0.041;r=-0.387,P=0.034).3?There was no significant correlation between serum inflammatory factors and activities of daily living(P >0.05).Conclusion:1?The serum levels of IL-2,IL-6,IL-10,TNF-? and IL-17 A in the AD group were significantly higher than those in the healthy control group,indicating that some of the serum inflammatory factors studied were related to the occurrence and development of AD disease and could be used as laboratory indicators for clinical diagnosis of AD in the future.2?There is a significant correlation between serum IL-17 A and MMSE,Mo CA and ADAS-cog in AD group.It is speculated that the level of serum IL-17 A factor may have a protective effect on the cognitive function of patients with AD.3?In patients with AD,there was no significant correlation between the level of serum inflammatory factors and the activities of daily living of dementia,indicating that the concentration of serum inflammatory factors could not be used as a potential blood biomarker for the impairment of activities of daily living of AD.