Alzheimer's Disease And Vascular Factors

Objectives: To investigate the risk of Alzheimer's disease (AD) associated with vascular factors and sociodemographic status, living style, smoking, eating habit, environmental exposure, family history of dementia. Methods: We conducted a population based, m:n matched case-control study on 402 AD patients, and 384 controls matched for age, sex and education. Univariate and multivariate analysis was conducted using conditional Logistic model. Results: In multivariate analysis , stroke history was found to have significantly effect on AD compared with those without stroke (0R=2.91, P=0. 0029) , and the OR(Odds ratio) for AD increased with the times of stroke. Compared with normal blood individuals, the OR for AD was 1.460 for those with hypertension (P=0. 0978) . the OR was 1. 564 for individuals of age 25-50 years old high fat intake more than once per month compared with those less than once per month. regular tea drinking habits (the OR was 0.770 for individuals drunk tea 1-3 times per month compared with non-drinker) were found to be protective factors for AD. High economic level and planting crop over 50 years old were protective factors for AD(OR=0. 542, P=0. 0062; 0R=0. 509, P=0. 0136) . Conclusion: This preliminary case-control study suggested that vascular factors are associated with AD. There is dose-response association between the vascular factors and AD. And the vascular factors are before AD occurs except stroke which cannot be ascertained. Vascular factors may be an etiology for AD. Besides, economic levels and planting crop over 50 years old also had association with AD. The study suggested that AD was a polyetiologic disease and it also benefited to therapy and prevention of AD.