The Study Of The Correlations Of Plasma Homocysteine Levels With Alzheimer Disease And Vascular Dementia

Objective: To explore the correlations of plasma homocysteine levels with Alzheimer disease and vascular dementia and its mechanism of inducing AD and VD.Design: a non-randomized control study based on diagnosis.Setting and Participants: Thirty AD inpatients or outpatients (AD group) and thirty-seven VD inpatients or outpatients (VD group), admitted from May 2008 to February 2009 to Qilu Hospital of Shandong University, were selected as our participants. All of the patients were finally diagnosed cases and had no other complications such as heart disease, hepatic disease, renal disease and so on. Twenty-eight healthy normal elders who took the health examination at the same time period were recruited to the control group.Methods: 2 ml elbow vein blood was withdrawn at fast state in the morning. After the samples were collected in EDTA test tube, centrifugated within four hours, and then the plasma was taken out, serum homocysteine was measured with fluorescence biochemistry quantitative assay. The kits were provided by Jinan XingEn Biotech Limited Company. Batch No.: HCY-07 Exp. Date : Feb.08. Index No.: YZB/JNHCY-01-2005.Main Outcome Measures:①differences of HCY level in the AD group and the control group.②differences of HCY level in the VD group and the control group.③differences of HCY level in the AD group and the VD group.Results: The level of plasma HCY in the AD group[14.57±4.49μmol/L] wassignificantly higher than that of the control group[10.96±3.87μmol/L]. There wasextremely significant difference between them (t=3.27, p<0.01). The plasma HCY inthe VD group[18.81±9.82μmol/L] was significantly higher than that in the controlgroup[10.96±3.87μmol/L]. The differences were significant (t=4.00, p<0.01). Therewas no significant difference between the AD group and the VD group (t=2.19,P>0.01) .Conclusion: There was positive correlation between Hhcy and AD/VD. Hhcy may bean important risk factor for AD and VD. It enhanced the correlation between AD andblood vessel risk factor as a new one. This study indicated that it maybe make positivesignificance in the direction of preventing AD and VD to degrade the plasma HCYlevel.