Study On The Correlation Between Cognitive Function And Blood Lipid And Homocysteine Levels In Senile Dementia

Objectives: To investigate the correlation between serum lipid,homocysteine(Hcy)levels and senile dementia {Alzheimer's disease(AD)and Vascular dementia(VD)}and the severity of dementia.Methods: Collect 2015.09-2018.08 in the first handan city hospital between 65-80 years 46 patients with AD,60 cases of VD patients and 50 cases during the same period in the first handan city hospital for medical examination between 65-80 years with no cognitive dysfunction in the elderly of serum total cholesterol(TC),triglyceride(TG),high density cholesterol(HDL-C),low density cholesterol(LDL-C),Hcy levels,MOCA score values and MMSE score values.To observed the correlation between serum lipid and Hcy levels in AD group,VD group and control group.Patients with AD and VD were divided into two groups according to MOCA score and MMSE score.The effects of serum lipid and Hcy levels on cognitive function were understood by comparing the blood lipid and Hcy levels of the two groups.Results:1.Serum levels of TC,TG,Ldl-c and Hcy in AD group and VD group were significantly higher than those in control group(P<0.05).There was no significant difference in serum Hdl-c levels between AD group,VD group and control group(P>0.05).2.There were no significant differences in serum TC,TG and Ldl-c levels between AD group and VD group(P>0.05).Serum Hcy level in VD group was significantly higher than that in AD group,and the difference was statistically significant(P<0.05).3.There were no significant differences in serum TC,TG,Ldl-c and Hdl-c levels between the High and low cognition two groups(P>0.05),while The serum Hcy level of the low cognitive group was significantly higher than that of the high cognitive group,and the difference was statistically significant(P<0.05).4.Serum Hcy level was negatively correlated with MOCA score and MMSE score in AD group and VD group.Conclusions: 1.Serum TC,TG,Ldl-c and Hcy levels are related to the incidence of dementia.2.Serum Hcy level is correlated with the decline of cognitive function in AD and VD patients,and the serum Hcy level is negatively correlated with the cognitive fu-ction level,MMSE and MOCA scores in AD and VD patients.3.Serum Hcy level in the VD group was significantly higher than that in the AD group,indicating that it is more necessary for VD patients to pay attention to the changes in serum Hcy level.4.The elderly should have their serum TC,TG,Ldl-c and Hcy levels monitored by annual physical examination.Early detection and early intervention may play a preventive role in the occurrence of senile dementia.