Level And Clinical Significance Of Serum Adiponectin And C-reactive Protein In Patients With Acute Cerebral Infarction

Objective:We measured serum adiponectin (ADP) and C-reactive protein (CRP) levels in patients with acute cerebral infarction, To investigate the relationship between the severity of the disease and the levels of ADP and CRP, the relevance of ADP and CRP, the clinical and pathophysiology implication of ADP and CRP in acute cerebral infarction.Methods: Patients with acute cerebral infarction group for 28 cases; 20 cases of healthy control group, in line with the income group of standards, in terms of age, gender composition comparable (P>0.05). By enzyme- linked immunosorbent assay (ELISA method) and the rate nephelometry method were used to detect the two groups of ADP and CRP serum levels were observed in patients with acute cerebral infarction within 48 hours of onset and the first 10 days after admission ADP and CRP serum levels. Of patients with acute cerebral infarction in patients with neurological deficits of the extent of the use of U.S. National Institutes of Health Stroke Scale (NIHSS) assessed. NIHSS score will be based on neurological impairment is divided into the following levels: <4 points, mild neurological dysfunction; 4~15 minutes, in order to moderate neuro- logical deficits;>15 with severe neurological dysfunction. The results of the use of statistical software SPSS10.0 statistical processing, the composition of the sample than amongχ2 test, CI group and control group sample was used to analyze the diff- erences between the two independent samples t test; cerebral serum ADP, CRP levels Analysis using paired t test; bivariate correlation between the single-factor analysis of the use of linear correlation analysis, a significant test of the standard test for bilateral P <0.05. Results:1.Pathogenesis of cerebral infarction within 48 hours of serum ADP level was significantly lower than the control group and the serum CRP level was significantly higher (P<0.05). The 10th day of admission serum ADP, CRP levels compared with the control group there was no significant difference.2.Infarction patients admitted to hospital 10 days after the serum ADP levels within 48 hours of onset was significantly higher (P<0.05), serum CRP levels 10 days after admission than 48 hours, the incidence decreased significantly(P<0.05).3.Pathogenesis in patients with cerebral infarction within 48 hours of severe NIHSS score showed a lower level of serum ADP significantly more severe than the mild, moderate group was significantly lower (P<0.05), and severe levels of serum CRP is more obvious severe than the mild group, moderate group was significantly higher (P<0.05).4.Pathogenesis in patients with cerebral infarction within 48 hours of serum CRP level and the level of ADP was a negative correlation (P<0.05).Conclusions:1.Patients with acute cerebral infarction within 48 hours of admission serum ADP levels were significantly lower, serum CRP levels were significantly increased, suggesting that ADP and CRP may be involved in the occurrence of acute cerebral infarction and the development of inflammatory response may be the occurrence of acute cerebral infarction in the course of development play an important role.2.Hospitalized patients with acute cerebral infarction within 10 days after the first 48 hours than the incidence of serum significantly increased ADP levels, and serum CRP levels decreased significantly, suggesting that serum ADP, CRP levels and the occurrence of acute cerebral infarction is closely related to development.3.Patients with acute cerebral infarction within 48 hours NIHSS morbidity score and serum ADP level was negatively correlated with CRP level was positively correlated. Serum prompted ADP, CRP levels may help detect patients with acute cerebral infarction on early diagnosis and determine the extent of the disease. 4.Acute cerebral infarction patients with serum CRP level and the level of ADP was negatively correlated, suggesting that ADP and CRP are closely related. Low ADP and high CRP levels may be the interaction between the occurrence and development of acute cerebral infarction an important factor in acute cerebral infarction for the prevention and treatment to provide a new way of thinking.