Clinical Application Of Carotid Ultrasound And Contrast-Enhanced Ultrasound Combined With Adiponectin And Hs-CRP In Atherosclerotic Cerebral Infarction

ObjectiveTo explore the risk factors of cerebral infarction, and to analysis the features of carotid atherosclerotic plaque under the ultrasound and ultrasound enhanced and to explore the relationship between serum levels of adiponectin(ADP), high-sensitivity C-reactive protein(hs-CRP) and carotid atherosclerotic.Methods70 patients with acute atherosclerosis sclerotic cerebral infarction were collected from March 2014 to July 2015 in Neurology of Anhui Provincial Hospital. the experimental group included 45 males and 25 females and mean age was 64.58± 10.23 years old. They were confirmed anterior circulation infarction by CT or MRI.50 cases of healthy as control group, including 31 males and 19 females, at the same period. The mean age of them was 64.04±9.75 years old. All cases of control group had no history of stroke and brain MRI was normal, there were no clinical symptoms and signs of stroke. Detailed clinical data was collected including hypertension, high cholesterol, diabetes, smoking, drinking history etc. All cases were collected venous blood 6ml in two tubes in the next morning. One tube was for routine biochemical tests, and another tube was stored, which were used to detection of serum ADP and hs-CRP levels by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetric after all the samples collected together. Serum ADP and hs-CRP levels were compared between the two groups. Each case was arranged to do examination of carotid ultrasonography, recording plaque nature, location and number. Soft plaques of them were chose to do examination of contrast-enhanced ultrasound, recording the distribution of new blood vessels in the plaque. To investigate relationships between the nature and neovascularization of plaque and cerebral ischemic.Results1. High blood pressure, high blood sugar, high cholesterol and smoking may be a risk factor of cerebral infarction (P<0.05);2. Serum ADP levels in patients with cerebral infarction group were significantly lower than the control group, while serum hs-CRP levels were significantly higher (P<0.01);3. Serum ADP levels in patients with cerebral infarction of soft plaque were significantly lower than the control group, while serum hs-CRP levels were significantly higher (P<0.05);4. Serum ADP levels in patients with Ⅰ/Ⅱ plaque were significantly higher than patients with Ⅲ/Ⅳ plaques, while serum hs-CRP levels were significantly lower (P <0.05).Conclusions1. The type of carotid atherosclerotic plaques is closely related to cerebral infarction;2. the levels of serum hs-CRP and ADP are closely related to cerebral infarction and plaque stability;3. The neovascularization in plaque is closely related to the stability of plaque;4. Combined carotid ultrasound and ultrasound enhanced with serum ADP or hs-CRP can make contribution to assess the risk of cerebral infarction and guide clinical treatment and prevention.