Correlational Study On Traditional Chinese Medicine Phlegm-syndrome, Adiponectin, Hs-CRP And Carotid Artery Atherosclerotic In Patients With Cerebral Infarction

Objective:In patients with acute cerebral infarction, according to measuring and comparing the serum adiponectin, high-sensitivity C-reactive protein levels, blood-fat and carotid artery atherosclerosis, we are going to discuss the relationship between serum adiponectin, high-sensitivity C-reactive protein levels, carotid artery atherosclerosis and TCM Phlegm syndrome from the clinical point of view, to provide a theoretical basis for the cerebral infarction and the objective basis diagnosis of phlegm.Methods:According to diagnostic criteria,61 cases of patients with acute cerebral infarction were collected. They were also divided into two groups-Phlegm syndrome group and Non-phlegm syndrome group based on acute stroke patients Syndrome Diagnostic Criteria. The former included 31 cases, and the later included 30 cases. Using enzyme-linked immuno-sorbent assay (ELISA) we assayed serum adiponectin, high-sensitivity C-reactive protein, TG, TC, HDL, LDL of these patients with cerebral infarction within 24 hours after onset. Meanwhile, we determined carotid artery intima-media thickness (IMT), the quantity of the plaque, the character of the plaque, using color Doppler ultrasound.30 cases of normal control group were also collected. They were also assayed serum adiponectin, high-sensitivity C-reactive protein, TQ TC, HDL, LDL, and carotid artery. Then associated statistical analysis were made on all the datas of serum adiponectin, high-sensitivity C-reactive protein, TQ TC, HDL, LDL, carotid artery plaque and phlegm.Results:1, The serum adiponectin level of patients with acute cerebral infarction was lower than normal control group. The high-sensitivity C-reactive protein level of patients with acute cerebral infarction was higher compared with normal control group. Both of the difference was significantly (P<0.05).2, The serum adiponectin levels of both Phlegm syndrome group and Non-phlegm syndrome group were lower compared with normal control group. The difference was significant (P<0.05). The serum adiponectin level of Phlegm syndrome group was lower than Non-phlegm syndrome group. The difference was significant (P<0.05). The high-sensitivity C-reactive protein levels of both Phlegm syndrome group and Non-phlegm syndrome group were higher compared with normal control group. The difference was significant (P<0.05). The high-sensitivity C-reactive protein level of Phlegm syndrome group was higher than Non-phlegm syndrome group. The difference was significant (P<0.05).3, The TG, TC, LDL levels of both Phlegm syndrome group and Non-phlegm syndrome group were higher compared with normal control group. The difference was significant (P<0.05). The TG, TC, LDL level of Phlegm syndrome group was higher than Non-phlegm syndrome group. The difference was significant (P<0.05). The HDL levels of both Phlegm syndrome group and Non-phlegm syndrome group were lower compared with normal control group. The difference was significant (P<0.05). There was no significant difference about HDL level between Pphlegm syndrome group and Non-phlegm syndrome group (P<0.05).4, Using rank correlation analysis (spearman method), the correlation analysis of serum adiponectin and high-sensitivity C-reactive protein of patients with acute cerebral infarction showed that there was a negative correlation between the two (r=-0.528, P<0.05).The correlation analysis of serum adiponectin and blood-fat of patients with acute cerebral infarction showed that there was a negative correlation between serum adiponectin and TG, TC, LDL (P<0.01),and there was no significant correlation between serum adiponectin and HDL (P<0.05).5, The carotid artery intima-media thickness of both Phlegm syndrome group and Non-phlegm syndrome group were thicker compared with normal control group. The difference was significant (P<0.05). The carotid artery intima-media thickness of Phlegm syndrome group was thicker than Non-phlegm syndrome group. The difference was significant (P<0.05).6, The detection rate of carotid artery atherosclerosis plaque between Phlegm syndrome group and Non-phlegm syndrome group was compared no significant difference (P>0.05).7,65% of patients of Phlegm syndrome were unstable plaques,35% were stable plaques. Compared with Non-phlegm syndrome patients the difference was statistically significant (P<0.05).Conclusions:1, Serum adiponectin declined after onset of cerebral infarction. The serum adiponectin level of Phlegm syndrome group was lower than Non-phlegm syndrome group. Serum adiponectin was closely related to Phlegm syndrome.2, The high-sensitivity C-reactive protein of patients with acute cerebral infarction was higher compared with normal control group. High-sensitivity C-reactive protein was related to cerebral infarction. The high-sensitivity C-reactive protein level of Phlegm syndrome group was higher than Non-phlegm syndrome group. High-sensitivity C-reactive protein was related to Phlegm syndrome.3, The TG,TC, LDL levels of patient with acute cerebral infarction were higher compared with normal control group. The HDL level of patient with acute cerebral infarction was higher than normal control group. There was dyslipidemia in cerebral infarction patients. The TG, TC, LDL level of Phlegm syndrome group was higher than Non-phlegm syndrome group. But there was no significant difference of HDL level between Phlegm syndrome group and Non-phlegm syndrome group. Blood-fat was related to Phlegm syndrome.4, The analysis showed that there was a negative correlation between serum adiponectin and high-sensitivity C-reactive protein, TG, TC, LDL. Serum adiponectin may have anti-atherosclerotic effect.5, The carotid artery intima-media thickness of cerebral infarction patients was thicker compared with normal control group. The carotid artery intima-media thickness of Phlegm syndrome group was thicker than Non-phlegm syndrome group. The carotid artery intima-media thickness was related to Phlegm syndrome. The detection rate of carotid artery atherosclerosis plaque between Phlegm syndrome group and Non-phlegm syndrome group was compared no significant difference.The unstable plaques of Phlegm syndrome group were more than Non-phlegm syndrome group. The carotid atherosclerotic plaque is the risk factors for cerebral infarction. The unstable plaques was related to phlegm syndrome.