Immune Function Condition Of Patients With Gastric Cancer And Function Changes Perioperatively

Objective: To analyze the relationship of peripheral blood lymphocytes immune function of the patients with gastric cancer to the clinical pathological stage (TNM) and the effection of operation to immune function.Methods: Flow cytomery was employed for detecting six indexes, including T lymphocytes antigen (CD3, CD4, CD8, CD4/CD8), NK cell antigen(CD16+56) and active lymphocytes antigen of 20 healthy persons, 18 Gastric ulcer and 80 gastric cancer patients. Furthmore, contrast the results of 80 gastric cancer patients perioperatively.Results:1.The CD3,CD4,CD8,CD4/CD8,CD16+56,CD25 of patients with Gastric ulcer was not lower than that from health people. 2.The cell immunity of patients with gastric cancer was so low that CD3, CD4, CD16+56 positive cell and CD4/CD8 ratio of gastric cancer patients were much less than those of the control(P﹤0.05). While CD8 positive cells was far more than those of the control(P﹤0.05). The CD3+/CD25+ cells have no obvious difference compared with the control(P﹥0.05). 3. For the 80 gastric cancer patients who received operation, CD3, CD4, CD16+56 positive cells and CD4/CD8 ratio are remarkably improved after the course(P﹤0.05), which had statistic difference compared by that before the course,meanwhile CD8 positive cells declined obviously (P﹤0.05),but had notable meaning comparing to those of the control yet (P﹤0.05). 4. For the 11 gastric cancer patients who received palliative surgery, CD3, CD4,CD16+56 cells and CD4/CD8 ratio improved remarkably after the course(P﹤0.05),which had statistic difference compared by that before the course, meanwhile CD8 cells declined significantly(P﹤0.05), but have notable meaning comparing to those of the control(P﹤0.05). Conclusion: 1. The immune function of T lymphocyte subsets , NK cellsand CD25 in patients was not low obviously, but the immune function of T lymphocyte subsets and NK cells in peripheral blood of the patiens with gastric cancer was very low, the change was related to the TNM pathological stage, the condition was even worse in the lower grade of TNM stage; the expression of CD25 had not apparente correlation to the immune function of organism. 2. The surgery operation could relieve tumorous immunosuppression to the patients with gastric cancer, improved the immune function widely. Furthmore, the immune function of patients in the higher grade of TNM stage recovered quickly. The immune function of patients in theⅠrgrade of TNM stage recovered to normal level 8 days later afteroperation;.but because the influence of operation and anaesthetic, other patients did not recover to normal level in 8days. 3. The immune function of patients in theⅣgrade of TNM stage also could recovered consumedly after palliative surgery. 4. Immunodetection of patients with gastric cancers by flow cytometry could make us understand the immune function status of gastric cancers preferably, enhance the protection in Peroperative Period; we could evaluate the operation effect and prognosis by the postoperative immunodetection of patients with gastric cancers.