Chemokine Receptor CXCR5 Expression In Gastric Cancer And Its Clinical Significance

Objective: To investigate the expression of chemokine receptor CXCR5 in human gastric cancer cell lines and gastric carcinoma tissues and its clinical significance.Methods: Flow cytometry was performed to analyze CXCR5 expression in human gastric cancer cell lines, BGC-823, SGC-7901 and HGC-27. Immunohistochemistry and tissue-microarray were used to detect CXCR5 expression in human gastric cancer tissues and adjacent normal tissues from 90 patients.Results: The flow cytometry revealed that CXCR5 expression could be found in BGC-823, SGC-7901 and HGC-27 cells lines. The results of tissue microarray and immunohistochemistry showed that the ratio of higher CXCR5 expression in gastric cancer tissues is 52.87%.The CXCR5 expression level in patients with tumor size ≤ 2.8cm group was significantly lower than that in patients with tumor size >2.8cm(χ2=3.995,P=0.0456).There was no significant correlation between the expression of CXCR5 in gastric carcinoma and other patients’ clinical parameters(P>0.05). Survival analysis showed that, the overall survival rate of the patients with high CXCR5 expression trended poorer than that of the patients with low CXCR5 expression(P=0.0579, HR=1.810, 95%CI: 0.9803-3.341).Conclusions: CXCR5 is involved in the oncogenesis and progression in human gastric cancer.