Clinical Analysis Of The Correlation Of Serum IL-10 And Testosterone With Coronary Artery Disease

PrefaceRecent research has shown that inflammation plays a key role in coronary heart disease (CHD) and other manifestations of atherosclerosis,The relation between inflammation marker and CHD is becoming a research hot point ,but a few studies about the association of interleukin-10(IL-10) ,a anti-inflammatory cytokine ,and CHD were found. Be contrary to the traditional opinion, the results of some studies suggested androgen play a protective role in CHD.ObjectiveOne aim of this study was to evaluate the correlation of serum IL-10 and testosterone level with CHD and the severity of it ,anther aim was to evaluate the correlation of serum IL-10and testosterone level with risk factors of CHD.Materials and Methods387 patients (240 male and 147 female,Mean age 60.94±10.05 years) were divided into CHD group (n=239) and control group (n=148) according to the results of coronary angiography(CAG). CHD patients were divided into subgroups according to the number, Gensini score of lesions in the coronary arteries and clinical severity (the statue of stable coronary artery disease, unstable angina or acute myocardial infarction). Serum IL-10 and testosterone levels were measured by ELASA. Logistic regression and partial correlation analysis were used to evaluate the correlation of serum IL-10 and testosterone with CHD. partial correlation analysis were used to evaluate the correlation of serum IL-10 and testosterone with risk factors of CHD too. Results1.Serum IL-10 (39.08±14.22 vs 49.27±24.67 pg/ml, p<0.01) was significantly lower in the CHD group than in the control group. The partial correlation analysis result in subgroups showed that the correlation coefficient between IL-10 with number of lesions, gensini score and clinical severity of CHD was rs(number of lesions)= -0.25, P<0.001; rs (gensini score)=-0.20, P<0.05; rs(clinical severity)=-0.25, P<0.001, respectively.2. In the total cohort and the female patients , Serum testosterone had no different in control group and CHD group (2.49±1.25 vs 2.37±1.38 ng/ml, p=0.40 and 2.22±1.38 vs 2.11±1.07ng/ml,p=0.505).In male patients, Serum testosterone was lower in the CHD group(2.44±1.38 vs 2.85±1.56ng/ml, p=0.047),but the correlation analysis did not show association between testosterone and male CHD.3 .Multivariate step logistic regression analysis found that only smoking (OR 3.79, 95% CI2.09-6.84, P<0.01), Diabetes mellitus (OR 2.48, 95% CI 1.05-5.88, P<0.05), apolipoprotein B (OR 14.14, 95% CI 4.29-46.61,P<0.001) and IL-10 (OR 0.74, 95% CI 0.57-0.89, P<0.01) entered the model.4. Serum IL-10 level was negatively correlated to Total cholesterol (TC), Triglyceride (TG), apolipoprotein A-1 (apoA-1) and apolipoprotein B(apoB). Serum testosterone level was negatively correlated to apoA-1 and positively correlated to Lipoprotein(a). IL-10 and testosterone were not association with other risk factors of CHD.Conclusions1. Serum IL-10 level was not only significantly related to CHD but also correlated with the severity of it. IL-10 was a independent protective factor for CHD.2. Perhaps serum testosterone was not associated with CHD in patients of both genders.3. Among CHD risk factors,IL-10 and testosterone only association with few blood lipids factors.