Clinic Research About Serum Testosterone Level In Elderly Males With Coronary Atherosclerotic Heart Disease

Objective: to investigate whether serum levels of total testosterone and free testosteroneare associated with CAD in elderly men.Subjects and methods: the study was conducted on116elderly males who werehospitalized with a complain of chest pain, and were checked by elective coronaryangiography.79of them suffering from Different degrees of coronary artery stenosis (atleast1vessel suffering from≥50%stenosis) were classified in the CAD group.37ofthem with normal coronary were put in the control group. Firstly, according to thediagnostic criteria,22of CAD group was considered as stable angina pectoris,35ofthem was considered as unstable angina pectoris,the rest of them was considered as acutemyocardial infarction. Secondly, According to the the number of the lesions, these79males were classified into three subgroups:20of them were assigned in the single vesselsubgroup,38in the double vessel subgroup and the rest in the there vessel subgroup.Futhermore, The degree of coronary artery lesions were under the assessment of theGensini score. We classify the79elderly males into there subgroups with23cases putinto “0~12.00” subgroup,41cases put into “12.01~61.00” subgroup,15cases put into“61.01~180.0”subgroup. Meanwhile. we detected the body mass index, the waist hip rate,the carotid intima media thickness and also the levels of serum total testosterone,freetestosterone(by DAS-ELISA), fasting blood glucose, triglyceride, total cholesterol,high-density lipoproteincholesterol, low-density lipoprotein cholesterol, Apolipoprotein-a,high-sensitivity C-reactive protein, homocysteine.Result: cases with CAD has significant higher values of IMT, TT, FT, LDL-C, but theyhad lower values of hypertension story, diabetes history, smoking history, drinkinghistory, age, BMI, WHR, FBG, TC, TG, HDL-c, apoA, hs-CRP, Hcy in comparison to control group. By comparing diverse subgroups of the CAD cases, both the differencesof the TT and FT are statistically conspicuous (detached on the basis of the diagnosticcriteria, FTT=33.22,PTT＜0.05；FFT=17.80,PTF＜0.05. detached on the basis of the scopeof lesions, FTT=27.81,PTT＜0.05； FFT=15.35,PTF＜0.05. classified according to theGensini score ranks, FTT=19.75,PTT＜0.05；FFT=12.25,PTF＜0.05). Either the level ofTT(r=-0.673；p＜0.05)or FT (r=-0.423；p＜0.05)was in the inverse correlation with theGensini score.The level of TT and FT are also related to diversified dangerous factors ofCAD.The linear regression analysis uncovered direct relevance between the R score(attained after statistically correcting the Gensini score) and TT(r=-0.585,P＜0.05orbetween the R score and FT(r=-0.311,P＜0.05),with the literal is382.774(P＜0.05).Conclusion: The less number of plasma TT and FT in elderly male subjects may giverise to CAD. Both total testosterone and free testosterone are negative associated with theseverity of coronary atherosclerosis in elderly males.