The Correlation Between Serum Interleukin-37b Level And Severity Of Coronary Artery Stenosis In Patients With Coronary Heart Disease

Objective:To detect the change of serum interleukin-37b(IL-37b)and neutrophil lymphocyte ratio(NLR)between coronary heart disease(CHD)subunits and control group,investigate the correlation between Serum levels of IL-37 b and degree of coronary artery stenosis,and initially explore the effects and clinical significance of serum IL-37 b in the occurrence of CHD.Methods:Selected the patients with chest pain or tightness,the Second Hospital of Shanxi Medical University,Department of Cardiology,in January 2020 to October 2020.By history,physical examination,electrocardiogram,cardiac troponin I assay and hospital coronary angiography.Selected objects 88 were divided into 4 groups: AMI group of 23 cases,UA group of 30 cases,SAP group of 19 patients,16 cases of normal control group.According to the Gensini score of each group,patients with CHD were divided into extremely severe(18 cases),severe(18 cases),moderate(20 cases),mild(16cases)lesion group.Human IL-37 b ELISA kit was used to determine the level of IL-37 b in serum of each group.NLR was calculated according to the number of neutrophils and lymphocytes entered,and the change of IL-37 b and NLR expression in each group was analyzed.Results:(1)Gender,smoking history,drinking history,hypertension history,heart rate,systolic blood pressure,body mass index,total cholesterol,low density lipoprotein,alanine aminotransferase,creatinine,urea nitrogen,monocyte count,platelet,hemoglobin,uric acid,BNP and LVEF had no significant difference among each groups(P > 0.05).The age of the control group was younger than that of the AMI group,UA group and SAP group(P<0.05).The prevalence of diabetes,glycosylated hemoglobin,and aspartate aminotransferase in the AMI group were greater than those in the control group(P<0.05).The diastolic blood pressure of the AMI group was greater than that of the UA group(P<0.05).The left ventricular end-diastolic inner diameter of the AMI group was larger than that of the SAP group(P<0.05),and the troponin I and CK-MB of the AMI group were obviously greater than those of the UA group,SAP group and control group(P<0.05).The differences are statistically significant.(2)The serum IL-37 b and NLR of AMI and UA group was obviously greater than those in SAP group and control group(P < 0.05).The IL-37 b of AMI group was higher than that of UA group(P < 0.05).All are statistically significant.(3)The IL-37 b and NLR of the extremely severe lesion group were greater than those of the severe,moderate,and mild lesion groups(P < 0.05),and the IL-37 b of the severe disease group was greater than that of the moderate and mild disease groups(P <0.05).All are statistically significant.(4)Serum IL-37 b was positively correlated with cardiac troponin I,CK-MB,left ventricular end-diastolic diameter,BNP,glycosylated hemoglobin and Gensini score(P< 0.05),but not with LVEF and diastolic pressure(P > 0.05).Conclusion:(1)The levels of IL-37 b and NLR in patients with CHD were increased,and the increase was more obvious in patients with AMI,suggesting that IL-37 b may be involved in the inflammatory response of coronary heart disease.(2)Correlation between IL-37 b,NLR and degree of coronary artery stenosis in patients with CHD.(3)Serum IL-37 b was positively correlated with NLR,cardiac troponin I,CK-MB,left ventricular end diastolic diameter,BNP and glycosylated hemoglobin,suggesting that IL-37 b is expected to become an inflammatory marker for evaluating the condition of patients with coronary heart disease.