The Study Of Survival And Prognostic Factors Of Epithelial Ovarian Carcinoma

Objectives: The aim of this study was to evaluate survival results and to assess prognostic factors which have an impact on overall survival in Patients with epithelial ovarian carcinoma.Methods: From January 2002 to December 2005, 170 Patients with stages I-IV epithelial ovarian carcinoma admitted to shanxi tumor hospital for Primary treatment, were eligible for retrospective analysis. These Patients were given cytoreductive surgery and/or intraabdominal/intravenous combination chemotherapy . All operations were Performed by senior surgeons. Histologic sections were reviewed by the senior pathologist .Statistical methods included Kaplan-Meier survival curves, long-rank test and COX proportional harard regression model multivariate analysis .Results: 170 Patients of epithelial ovarian carcinomas. The survival rates of 1-,2-,3-,4-,5- year were 98.8%,87.1%,68.8%,35.1%,15.9%. Respectively; The Prognostic factors of epithelial ovarian carcinomas were related to age, FIGO stage, histologic type, Pathological differential grade, the size of residues and the number of chemotherapy treatment course.In univariate analysis and family history was not related to the survival of epithelial ovarian carcinoma .COX proportional hazard model confirmed that FIGO stage, the size of residues and the number of chemotherapy treatment course were significant Prognostic indicators in multiple factors analysis. The risk of mortality according to FIGO stage was 0.005 for FIGOI, 0.106 for FIGOII, 0.365 for FIGOIII; in comparison with FIGOIV. The risk of mortality according to the size of residues was 0.307 for the remaining lump diameter>2cm, in comparison with the remaining lump diameter≤2cm. Patients with <6 courses of chemotherapy had 8.191 times higher risk of mortality than Patients with≥6 courses of chemotherapy.Conclusion: FIGO stage, the size of residual tumor after Primary operation and the number of courses of chemotherapy are the major independent Prognostic factors of epithelial ovarian carcinoma. Therefore, Improving the earlier diagnosis to give the earlier treatment are the key point to improve the survival rates of epithelial ovarian carcinoma . Regular, Sufficient dosage, Sufficient cycles and Timely assistant chemotherapy are the necessary measures to improve the survival rates of epithelial ovarian carcinoma.