| Primary dysmenorrhea is one of gynecological diseases,and more fat in young women,clinical performance for the next major abdominal cramps and pain, has seriously affected the normal work of women living,learning,activities and work.In recent years,both at home and abroad on the pathogenesis of primary dysmenorrhea and treatment with further study,and achieved a lot. Chinese medicine for the treatment of dysmenorrhea have very good results, the consolidation effects,drug side effects,has a unique advantage.However, at home and abroad for research in this area is still less than that without depth.Chinese medicine for the treatment of the mechanism of dysmenorrhea, as well as how to develop and apply clinical,Chinese medicine has become a major research topic.Part One:Documents and theoretical studyReviewed the causes of primary dysmenorrhea and pathogenesis.The patho genesis of primary dysmenorrhea more complicated,mainly related to abnormal uterine contraction,endocrine factors,neural and neurotransmitters and magnesium ions,calcium ions,genetic factors,immune factors and the spirit, the environment,social movements and other relevant factors such as,one with prostaglandin most closely related.Treatment of primary dysmenorrhea,modern medicine emphasize pain,sedation and prostaglandin inhibitors,take effect quickly,but the adverse reactions,and efficacy can not be sustained;surgical treatment have some effect,but has its limitations,patients are not easily.Recalling the traditional Chinese medicine for primary dysmenorrhea understanding of pathogenesis.Studies suggest that Chinese medicine is its pathogenesis blood runs sluggish,circulation of blood cells by official obstruction,resulting in non-General pain;or Chong and Ren,cell loss in the Official breeing,not pain-jung.Treatment,the main methods are:traditional Chinese medicine treatment,the treatment of proprietary Chinese medicines,Chinese medicine outside the administration,such as acupuncture. In addition,primary dysmenorrhea,most clinical research,experimental study of normal,clinical research at the level of clinical observation,the lack of depth of research,and clinical and experimental research could not good combination.Wuji Baifeng Wan is common gynecological medicine,with Air Yangxue,Tiaojing only with the effect of clinically used for blood deficiency, physical weakness,weakness in back or knee,irregular menstruation,uterine bleeding such case taken off.Around the issue of the incidence of primary dysmenorrhea factors,combined with the effectiveness of the role of Wuji Baifeng Wan,Wuji Baifeng Wan explore the role of the treatment of primary dysmenorrhea.Part two:Experimental StudyObjectiveDysmenorrhea through rat model of experimental observation of Wuji Baifeng Wan for treatment of dysmenorrhea and to explore its mechanism.Through the isolated rat,in vivo,analgesic experiments,the experimental antiinflammatory, immune function experiments,anti-stress test and blood test to examine the treatment of primary dysmenorrhea Wuji Baifeng Wan Pharmacodynamic basis.Methods:(1) Experimental study on Pharmacodynamics of Wuji Baifeng Wan to the dysmenorrhea rats model:①the effect of Wuji Baifeng Wan on the writhing response of dysmenorrhea rats model;②the effect of Wuji Baifeng Wan on the endometrial PGF2α,PGE2' content of dysmenorrhea rat model。(2) the effect of Wuji Baifeng Wan on the normal contraction of isolated rats' uterus and the abnormal contraction of isolated rats' uterus induced by the oxytocin。(3) the effect of Wuji Baifeng Wan on the normal contraction of rats' uterine in vivo and the abnormal contraction of rats' uterine in vivo induced by the oxytocin。 (4) Experimental Study of analgesia:①the effect of Wuji Baifeng Wan on the pain in mice induced by the thermal stimulation:②the effect of Wuji Baifeng Wan on the Pain in mice induced by the acetate。(5) Experimental study on anti-inflammatory:①the effect of Wuji Baifeng Wan on the mice ear edema to induced by the xylene;②the effect of Wuji Baifeng Wan on the foot swelling in rats induced by the egg white;③the effect of Wuji Baifeng Wan on the cotton balls granuloma in rats。(6) Experimental study of the immune system:①the effect of Wuji Baifeng Wan on the weight of immune organs of mice;②the effect of Wuji Baifeng Wan on the Carbon particle clearance function of mice。(7) Experimental study of anti-stress:①fatigue experiment;②experimental hypoxia;③cold-resistant experiment。(8) The effect of Wuji Baifeng Wan on the of animal model of ischemic anemia。Results:Wuji Baifeng Wan could inhabit the writhing response of dysmenorrhea rats model,and could reduce the rats endometrial content of PGF2α,increased content of PGE2;Wuji Baifeng Wan couid inhabit the normal contraction of isolated rats' uterus,rats' uterine in vivo and the abnormal contraction of isolated rats' uterus,rats' uterine in vivo induced by the oxytocin;Wuji Baifeng Wan have a significant analgesic effect on Experimental model of thermal pain stimulation and experimental model of chemical stimulation of pain;Wuji Baifeng Wan have a good inhibition on acute inflammation model, could inhibit the mice ear edema to induced by the xylene,the foot swelling in rats induced by the egg white and the cotton balls granuloma in rats; Wuji Baifeng Wan could significantly improve the immune function of the lower model group,spleen,thymus factors and phagocytic index K,phagocytic indexα;Wuji Baifeng Wan could increase in loading mice swimming time,hypoxia in mice under normal pressure time and mice survival rate of mice under lowtemperature environment,but also significantly improve the model of blood loss anemia blood RBC and Hb.Conclusions:Wuji Baifeng Wan model for dysmenorrhea pain in rats produced a significant inhibition,which may be related to the lowering of rat endometrial PGF2αcontent,the content increased PGE2;for uterine contraction obvious ease with role At the same time has a good analgesic,anti-inflammatory and enhance immune function,vitality,such as the role of the blood.Its role in the treatment of primary dysmenorrhea may be related to the above-mentioned mechanism of role-related.
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