| ObjectiveStudies through the clinical own control experiment,the observation profit was mad whether the blood circulation class traditional Chinese medicine the use does intervene the maintenance hemodialysis patient blood vessel endothelial cell function effectively the unusuality.This research may provide the medication reference for the next clinical practice traditional Chinese medicine early time synthesis intervention maintenance hemodialysis patient blood vessel endothelial cell function.MethodIntegrates the blood to pass the center to enter the maintenance hemodialysis patient 100 examples,the selection present domestic and foreign research many can represent the MHD patient blood vessel endothelial cell function disorder aspect the designated object:ET-1,vWF.The experiment intervenes for 3 months, the treatment group,in the stable dialysis(3/weeks) and the conventional blood passes the medication in the foundation to give takes promotes blood circulation the oral 3 months,the control group only gives the stable dialysis and the conventional blood passes the medication,two group of patients avoid using other to invigorate the blood the removing extravasted blood traditional Chinese medicine or the anti-blood platelet antifreeze medicine.Around before the treatment extracts thoroughly,the blood sample separately,through clinical own control experiment,observation stable treatment MHD patient after taking promotes blood circulation the oral,the above designated object whether has the change,and the observation of primary mass data promotes blood circulation the oral whether can through the profit be mad the blood circulation the function, exceptionally carries on the early synthesis intervention to the blood vessel endothelial cell function,whether to prevent the MHD patient cardiovascular disease's occurrence and the reduced chronic inflammation response effectively. Simultaneously may seek affects ET1,the vWF correlation factor.ResultBlood plasma vWF,ET-1 content average value when initial integration during two groups of compares not obvious difference(both P＞0.05);The second survey verage value during good group compares the discovery existence remarkable difference(ET value P＜0.01,vWF value＜0.01).The treatment group applies drugs 3 months later before the blood plasma ET content is higher than the dialysis obviously,has statistics difference(P＜0.01),vWF around content not remarkable statistics difference(P=0.106).The control group second time examines ET1,the vWF value own around to compare compares the first content to elevate obviously, has statistics significance(P＜0.05).Demonstrated with the multi-dimensional stepwise regression analysis:Affects MHD the patient vWF level the factor is in turn:Dialysis time(Beta=0.437,P＜0.05);Average arterial pressure(Beta=0.397,P＜0.01);Total cholesterol(Beta=0.385,P＜0.01);Low density lipoprotein(Beta=0.378,P＜0.05),EPO amount used(Beta=0.189,P＜0.05), regression equation duplicate correlation coefficient r=0.687.Affects MHD patient ET-1 the level the factor is in turn:Hemoglobin(Beta=0.503,P＜0.01), dialysis time(Beta=0.408,P＜0.05).EPO amount used(Beta=0.185,P＜0.05), regression equation duplicate correlation coefficient r=0.253.ConclusionProotes blood circulation the oral to be possible to improve the maintenance blood to pass patient's blood vessel bast function.The chronic renal failure patient has the endothelial cell damage and the exogenetic hemoglutination system's start,this kind of change in the maintenance hemodialysis patient with the dialysis time,the average arterial pressure,the total cholesterol,the low density lipoprotein,the EPO amount used,the hemoglobin concerns.The hemodialysis this in vitro blood purification process aggravated the chronic renal failure patient's blood vessel endothelial cell function barrier and the hemoglutination mechanism unusuality. |
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