| ObjectiveTo comprehend the quantity and trends of literatures about clinical controlled trials of Traditional Chinese Medicine from 1989 to 2008. To evaluate the methodological and reporting quality of randomized controlled trials involving traditional Chinese medicine in the treatment of Essential Hypertension from 1989 to 2008.MethodsWe searched VIP(1989 to 2008.12) by computer search and manual search. Search the quantity of clinical controlled trials of Traditional Chinese Medicine published every year, and then try to analyse it quantitatively. Data from randomized controlled trials (RCTs) and quasi-RCTs were extracted. A comprehensive collection of Chinese medicine in the treatment of essential hypertension clinical randomized controlled trials of the research literature, where the text into a "random" words in the original target-onset diseases, Essential Hypertension research. The methodological quality of included trials was assessed by using the quality assessment criteria recommended by The Cochrane Collaboration, and the reporting quality was assessed by using the CONSORT for TCM checklist. And then analyse literatures by evidence-based medicine, systematic evaluation and Meta analysis of systematic reviews (meta-analysis) and Revman v5.0 software. Results1 Part 1Clinical controlled trials from the beginning of a gradual increase in 1995, of which the number of randomized controlled trials from the beginning of 1999 was a significant upward trend in non-randomized clinical randomized controlled trials from 1995 the number increased, but increased the speed of the slowdown since 2001, and in 2002 less on randomized controlled trials. Articles published from year to year than to look at composition, clinical randomized controlled trials was also the proportion of the gradual upward trend. Clinical controlled trials of Chinese medicine in the random and the ratio of non-random in 1989 from close to 0, to increase in 2008 is much larger than 2. Chinese medicine randomized controlled clinical trials with non-random component ratio and the ratio for both Runs Runs Test results showed that P <0.05, statistically significant, suggesting that Chinese medicine randomized controlled clinical trials with non-random component ratio and the Second From the last 20 years the ratiobetween the change would definitely be a non-random factors.2 Part 2A total of 79 included in the literature. to exclude the quality of an evaluation of the literature documents, one for Meta analysis of literature, review literature 2, article 2 with "randomized" the words but not the actual Sub-group randomized clinical controlled trials, and ultimately into the literature 73 randomized controlled trials literature. Evaluation results showed that the methodological quality of literature into a low, low quality of the research literature there are 66 (90.41%), only 4 (5.48%), referring to the allocation of concealment, as many as 64 (87.67%) were not mentioned blind, only 7 (9.59%) described the withdrawal or withdrawal. The CONSORT for TCM for 27 hours, a minimum of only 7 points, average score only 14 points. All included in the study prompted the report of low quality. Among them, in the title and summary, of the specific purposes and assumptions of the standard subjects in each group to intervene in the accurate information, baseline data, in accordance with the order of primary and secondary indicators to describe and discuss the results and interpretation of research findings described in 8 aspects of the report is more complete; and in the introduction and background, set the principle of the control group, sample size estimation, randomization allocation concealment, randomization implementation, set up the blind case, the success of blind, additional analysis of changes in process were plans to conduct follow-up and data collection, analysis of subjects in each group the number of effective, whether or not the use of ITT, at the same time that the relative number and absolute results of the effect of volume size and precision, support analysis, analysis of potential bias and influence factors can promote, and all 18 items of evidence, all included in the study are obviously insufficient.3 Part 3Finally, a total of 24 included in the literature over the past 20 years concerning the treatment of essential hypertension in Chinese medicine clinical research literature of randomized controlled trials, the use of evidence-based medicine, literature and Meta analysis of systematic reviews (meta-analysis) methods, the use of analysis software Revman v5. 0 reached the following conclusions:3. 1 Pure Chinese medicine treatment, the systolic blood pressure of essential hypertension and antihypertensive effect of western medicine simply no significant difference between the control group, but does not mean that they completely equivalent.3. 2 Pure Chinese medicine treatment, the diastolic blood pressure of essential hypertension and effects of western medicine simply no significant difference between the control group, but does not mean that they completely equivalent. 3. 3 In the effective treatment of systolic blood pressure better than western medicine treatment, systolic blood pressure after treatment and about the former than the latter low 7. 33mmHg.3.4 In the effect of the treatment of diastolic blood pressure significantly better than western medicine treatment, diastolic blood pressure after treatment and about the former than the latter low 4. 85mmHg.3.5 In the total effective antihypertensive therapy is superior to Western medical treatment alone, the former step-down the total effective rate of approximately 1. 12 times the latter.3. 6 Chinese and Western Medicine triglyceride lowering effect of significantly better than western medicine treatment, after treatment the former than the latter about low triglyceride 0.64 mmol/L. CondusionOver the past 20 years, the quantity of randomized controlled trials of Traditional Chinese Medicine in terms of both absolute number or proportion of the rising trend year by year. The quality of RCTs involving traditional Chinese medicine for Essential Hypertension is generally low, with a high risk of biases. The reporting of these trials is also incomplete, which would affect a reader's understanding and evaluation of the validity, importance and applicability of the study results. Therefore, new randomized controlled trials of high quality are required to provide reliable evidence. According to available information found in purely medical treatment of essential hypertension and antihypertensive effects of western medicine simply no significant differences in the basis of western medicine with Chinese medicine combined with increase in the treatment of essential hypertension, the systolic blood pressure decreased diastolic blood pressure the step-down effect, as well as the total effective rate of relief, such as triglyceride levels after treatment, the advantages are obvious.
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