Experimental Study On The Effect Of Cinnamon Twig Decoction On Serum Eosinophils In Asthmatic Rats

Objective:Asthma is a chronic inflammatory disease of the airway influenced by increased eosinophilia,the numerous goblet cells,the secretion of mucus and has a high response with inhale allergens and nonspecific stimulation, among them eosinophilia's recruitment together with activation after have play an important role in the pathogenesis of asthma.Now the discussion about building asthma animal models used by OVA on clinical is comparative maturity, which that provides favorable experiment conditions to finding a availability cure for asthma.The TCM Prescription of Cinnamon Twig Decoction has been shown to be an efficacious for Endocrine Disease,as well as asthma,but there is scarcely discussed for cruing asthmatic rats.The experimental established in the eosinophilia development of asthma through studying the effect of number of eosinophilia in asthmatic rats by the treatment of Cinnamon Twig Decoction.Methods:For studying the effect of number of eosinophilia in asthmatic rats under the questions by using Cinnamon Twig Decoction to treat asthma on clinical observation.40 SPF male rats were divided into 4 groups which categorized as follows:normal control group,model group,Cinnamon Twig Decoction group,Dexamethasone group.Choose the model rats of asthma,Cinnamon twig decoction of asthma and dexamethasone group sensitized with ovalbumin (OVA),others are saline water,the changes of the delitescence of asthmwas bserved;carry out t test in tow sets,variance analysis in multi-sets by counting the number of eosinophilia in rats.Results:Compare with normal control group,that number of eosinophilia of model group decreased remarkably(P＜0.05).Discovering that number of eosinophilia of Cinnamon Twig Decoction group decreased remarkably and have obvious difference compared withp atho-model group and Dexamethasone group(P＜ 0.05).Cinnamon Twig Decoction is very effective at lowering eosinophilia levels.Discovering that Cinnamon Twig Can relieve inflamed cells sinfiltrating obviously,and the efficacy of Cinnamon Twig Decoction is far exceeds that of Dexamethasone in asthmatic attack.Conclusion:Cinnamon Twig Decoction has obviously effects of treating asthma and its mechanism is due to the decrease of the number of eosinophils.