The Relationship And Significance Among NF-κB,MCP-1 Expression And Macrophage Infiltration In Human Ovarian Cancer Tissue

Objective:To approach NF-κB,MCP-1,CD68marked macrophage expressed in ovarian cancer and the correlation with clinical pathological characteristics and the dependability of the three by detecting NF-κB,MCP-1,CD68marked macrophage in human ovarian cancer tissue,and accordingly it may help to find new ways to diagnose and treat ovarian cancer.Methods:80 archive specimens of ovarian cancer were assessed by immunohistochemistry assay.We then approach the expression of NF-κB,MCP-1,CD68marked macrophage in human ovarian cancer tissue,the correlation with clinical pathological characteristics and the dependability of the three by detecting NF-κB,MCP-1,CD68marked macrophage in human ovarian cancer tissue.Results:1. The positive rate expressed by NF-κB in ovarian cancer is significantly higher than in benign and borderline ovarian tumor. The positive rate expressed by NF-κB in ovarian cancer is increasing with the histological grade of ovarian cancer,but only the difference between the poor differentiated group and the middle,well differentiated group of significance. The positive rate expressed by NF-κB is different significantly in clinical stage(early stage,advanced stage) and CA125(<600U/ml,≥600U/ml).But there is no significantly difference in pathological type(serosity,non-serosity),tumor size(<10cm,≥10cm), age of the patients(<50,≥50),ascitic fluid volume(≤500ml,>500ml). 2. The positive rate expressed by MCP-1 in ovarian cancer is significantly higher than in benign and borderline ovarian tumor. The positive rate expressed by MCP-1 in ovarian cancer is increasing with the histological grade of ovarian cancer,but only the difference between the poor differentiated group and the well differentiated group of significance. The positive rate expressed by MCP-1 is different significantly in histological grade of ovarian cancer (early stage,advanced stage) and CA125(<600U/ml,≥600U/ml).But there is no significantly difference in pathological type(serosity,non-serosity),tumor size(<10cm,≥10cm), age of the patients(<50,≥50),ascitic fluid volume(≤500ml,>500ml).3. The positive rate expressed by CD68marked macrophage in ovarian cancer is significantly higher than in benign and borderline ovarian tumor. The positive rate expressed by CD68marked macrophage in ovarian cancer is increasing with the histological grade of ovarian cancer,but only the difference between the poor differentiated group and the well differentiated group of significance. The positive rate expressed by CD68marked macrophage is different significantly in clinical stage(early stage,advanced stage) and CA125(<600U/ml,≥600U/ml).But there is no significantly difference in pathological type(serosity,non-serosity),tumor size(<10cm,≥10cm), age of the patients(<50,≥50),ascitic fluid volume(≤500ml,>500ml).4. NF-κB protein is mostly expressed by ovarian cancer cells .The expression of NF-κB is significantly positive correlation with the expression of MCP-1 and CD68marked macrophage.5. MCP-1 protein is mostly expressed by ovarian cancer cells . The expression of MCP-1 is significantly positive correlation with CD68marked macrophage.Conclusions:1. NF-κB protein and MCP-1 protein are mostly expressed by ovarian cancer cells.2. NF-κB, MCP-1, CD68 marked macrophage have correlation with histological grade of ovarian cancer, clinical stage and CA125. But they have no correlation with age of patients,tumor size,ascitic fluid volume and pathological type.3. The expression of NF-κB,MCP-1 and CD68 marked macrophage in ovarian cancer is significantly positive correlation with each other.