Study Of Pharmacodynamic Of Fenghanganmao Dispersible Tablets Extract

Cold which has catarrh symptom is the most popular respiratory tract contagion. Most people will feel swirl,headache,abdominal distention,alvi profluvium,bad appetite,limbs pain,debilitation and the temperature of body will rise up.Symptoms which are heat cold,little fever,absent sweating,body and head pain,stuffy nose with watery discharge,cough and white sputum,not thirsty or like hot drink,lingual fur thin and white is called anemofrigid cold by Chinese tradition medicine and acrid-warm herbs relieving superficies treat should be mainly used.The animal experiments were used to test the improved Fenghanganmao dispersible tablets extract's anti-inflammatory,analgesic and antipyretic,immune function and antitusis effect based on Fenghanganmao tablets' diaphoresis relieving superficies and expelling wind and cold function.This experiment tested the Fenghanganmao dispersible tablets extract's which improve the way of array agent extraction and dosage form pharmacology to study its affect of drug action,treat arrange and so on.1.The models that mice ears swell induced by dimethylbenzene and abdomen capillary permeability in mice induced by acetic acid were used to observe anti-inflammatory of Fenghanganmao dispersible tablets extract,every group was dosed with method of lavage.The result shows that the Fenghanganmao dispersible tablets extract has significant ears swell and capillary permeability inhibit function(P＜0.01) at dose of 10.4 g(crude drug)/kg,at the dose of 5.2,2.6 g(crude dru ) /kg it also has obvious inhibit function.The result indicates that Fenghanganmao dispersible tablets extract has anti-inflammatory function.2.The pain models were established by acetic acid and hot plate in mice,every group was dosed with method of lavage.The result shows that Fenghanganmao dispersible tablets extract significant raise the threshold of the pain(P＜0.01) in the test of writhing induced by acetic acid at the dose of 10.4,5.2 g(crude drug) /kg,at the dose of 2.6 g(crude drug) /kg it also has obvious raise(P＜0.05);in hot plate thermal stimulus test 10.4 g(crude drug) /kg Fenghanganmao dispersible tablets extract significant raise the threshold of the pain(P＜0.001) at the time of 30,60,90min,5.2 g (crude drug) /kg dose has obvious raise(P＜0.05).The result indicates that Fenghanganmao dispersible tablets extract has analgesic function.3.Antipyretic action was surveyed by pyretic induced by injecting 2,4-dinitrophenol or fresh yeast subcutaneously in rats,every group was dosed with method of lavage.The dose of 10.4 g(crude drug)/kg Fenghanganmao dispersible tablets extract has significant antipyretic function(P＜0.01) at the 0.5,1.0h in 2,4-dinitrophenol test and dose of 5.2 g(crude drug) /kg has obvious antipyretic function(P＜0.05) at the 0.5h;in yeast test dose of 10.4 g(crude drug) /kg has significant antipyretic function(P＜0.01) at the 1.0h and has obvious antipyretic function(P＜0.05) at the 0.5 and 2.0h,5.2 g(crude drug) /kg dose also has obvious antipyretic function(P＜0.05) at the 0.5 and 1.0h.The result indicates that Fenghanganmao dispersible tablets extract has antipyretic function. 4.Erythrocytolysin antibody levels and macrophage mononuclear celiac macrophage phagocytic activity in mice were tested to study its immune function, every group was dosed with method of lavage.The result shows that 10.4 g(crude drug)/kg dose Fenghanganmao dispersible tablets extract significant enhance both macrophage phagocytic activity and erythrocytolysin antibody levels(P＜0.001);5.2 g (crude drug) /kg dose has obvious effect on index of phagocytosis and erythrocytolysin level(P＜0.05).It also has significant effect on percentage of phagocytosis(P＜0.01).The result indicates that Fenghanganmao dispersible tablets extract has immune function.5.Antitusis effect is observed by counting the cough times induced by ammonia solution of mice and guinea pig,every group was dosed with method of lavage.All dose of 10.4,5.2,2.6 g(crude drug)/kg Fenghanganmao dispersible tablets extract can significant relieve mice cough(P＜0.001),10.4,5.2 g(crude drug)/kg dose significant relieve guinea pig cough(P＜0.001).The result indicates that Fenghanganmao dispersible tablets extract has antitusis function.The experiments indicate that Fenghanganmao dispersible tablets extract has good effect on anti-inflammatory,analgesic,antipyretic,immune function,antitusis and has dose-effect relationship.Fenghanganmao dispersible tablets extract compare to same dose of Fenghanganmao granula has the obvious effect on immune function and antitusis(P＜0.05),difference on anti-inflammatory,analgesic,antipyretic is not significant but dispersible tablets extract has more effect tendency,it shows dispersible tablets extract's superiority.