Hyaluronic Acid Intra-articular Injection With The Oral Treatment Of Osteoarthritis Of The Knee Yishen Juanbi Pills Experimental Study

Objective:osteoarthritis of the knee known as knee osteoarthritis,the elderly are a health hazard in chronic progressive osteoarthritis,bone disease of the joints after the neck,the third lumbar vertebra,bone joint disease ranked first.The main pathological features of articular cartilage degeneration,destruction,subchondral sclerosis,articular cartilage edge and reactive hyperplasia of bone,osteophyte formation.Statistics show that the number of our country suffering from OA of the total population of 3%,with most of KOA,55-year-old crowd KOA has more than X-line performance by about 60%,65 years old X-line has the incidence of KOA rate of up to 85%.With the aging population,the incidence of the disease more and more,and the complexity of the disease condition,a longer course of disease,treatment is difficult, not only brought great pain patients,but also to society and has brought home heavy burden.At present,the treatment of this disease there are still limitations,medication often choose non-steroidal drugs,analgesics and even hormones,but no long-term efficacy andside effects.For osteoarthritis of the knee articular cartilage degeneration is,destruction, subchondral bone sclerosis as the main pathological characteristics of our clinical use of intra-articular injection of Hyaluronic Acid with with Yishen Juanbi pills treatment of oral KOA achieved good long-term therapeutic effect and significantly reduced adverse reactions.In order to clarify the efficacy of the treatment results,to carry out "Hyaluronic Acid intra-articular injection with the oral treatment of osteoarthritis of the knee Yishen Juanbi pills Experimental Study" subject.Methods:The collection of my out-patient section of the 2007-2008 cases of osteoarthritis of the knee,after six months follow-up, according to the treatment combination of features is divided into one group,combined with 2 group,HA group and traditional Chinese medicine groups,each of the 30 cases of cases, statistics,researchResults:Clinical research has shown that:1 Hyaluronic Acid intra-articular injection with the oral Yishen Juanbi pills treatment group(combination of one group) in the treatment of knee osteoarthritis has 96.88%efficiency;Hyaluronic Acid intra-articular injection with oral Diclofenac Sodium Enteric-coated Tablets treatment group(2 groups combined) in the treatment of knee osteoarthritis was 88.89%efficient;Hyaluronic Acid intra-articular injection treatment group(HA group) in the treatment of knee osteoarthritis has 72.41%efficiency;Yishen Juanbi pills oral treatment group(Chinese Medicines) in the treatment of knee osteoarthritis has 56.25%efficiency;Ridit After analysis,the effect of combined treatment of one group and the incidence of adverse reactions are better than combining 2 groups,HA group, and the traditional Chinese medicine groups.2 Injection of Hyaluronic Acid treatment with the oral Yishen Juanbi pills and Hyaluronic Acid intra-articular injection with oral Diclofenac Sodium Enteric-coated Tablets treatment,knee osteoarthritis can improve clinical symptoms and reduce joint pain and improve joint function,after Ridit analysis,combined with 1 group are better than long-term treatment combined with 2 group,HA group,and the traditional Chinese medicine groups.3 Yishen Juanbi pills oral treatment with intra-articular HA injection treatment,applied at the same time when the treatment of knee osteoarthritis with synergy.Conclusion:Clinical studies have confirmed that intra-articular sodium hyaluronate injection with the oral pill Juanbi Yishen treatment can significantly reduce joint pain and improve joint function and alleviate symptoms,after Ridit analysis,combined with 1 group are better than long-term treatment combined with 2 group,HA group,and the traditional Chinese medicine groups. Prove that Yishen Juanbi pills oral treatment with intra-articular HA injection treatment,applied at the same time when the treatment of knee osteoarthritis with synergy, has good long-term efficacy and lower incidence of adverse reactions and toxic side effects.May be by reducing the inflammatory response,lubrication of articular cartilage and improve the clinical symptoms,such as ways to achieve.