Effects Of Nutritional Support On Nutritional Status And Immunal Function Of Patients At Early-Stage Following Surgery For NSCLC

Objects:to evaluate the changes of nutritional status and immunal function in patients of non-small cell lung cancer(NSCLC),and those at early-stage following surgery, attempting to analyse the correlations of nutritional status and immunal function for patients of NSCLC at early-stage postoperatively,to assess the effects of nutritional support on cellular and humoral immunal function during that-stage.Methods:65 NSCLC patients were randomized to divide into two groups:Nutritional Support Group(NSG)(M28,F7,Mean 52.6 years) and Non-Nutritional Support Group (NNSG)(M20,F8,Mean 51.9 years).The patients were transfused nutritional elements via peripheral vena during the 1^st to 5^th day postoperatively,when they took foods in NSG,The caloric in which contained 20 Kcal/Kg.d^-1,nitrogen 0.2g/Kg.d^-1.The patients were only allowed to take food during the same time in NNSG,the venous caloric was below 200 Kcal/d.The blood samples were obtained in all patients pre-operatively,1^st and 7^th postoperatively to detect nutritional status,lymphocyte subsets,and immunoglobulins.The data were statistically analysed by SSPS 10.0.Results:to compare the data between the two groups,all values were decreased in the 1^st day postoperatively than pre-operatively.However,to compare the values in the 7^th day postoperatively with pre-operatively,in NSG,there could find out PA level, TFN level,the percents of CD₃⁺,CD₄⁺,NK,CD₁₉⁺,the ratio of CD₄⁺/CD₈⁺ to increase, but the percent of CD₈⁺ was decreased;in NNSG,TFN level,the percents of CD₃⁺, CD₄⁺,CD₈⁺,NK,CD₁₉⁺ to decrease,PA level to increase.To compare the values between the two groups,these variances were significant.However,the significance of immunoglobulins was little.Conclusions:Malnutrition and immunodeficiency,particularly for cellular immunodeficiency had been presented in NSCLC in early-stage following surgery. Though the diet was inavailable for the bad status,nutritional support was responsible for correcting the malnutrition status,and improving the host's anti-tumor immune, especially the cellular immune,and hence,shortening the recovery time of the host's cellular immune.