Association Of High-sensitivity C-reaction Protein With Prehypertension

ObjectiveTo observe difference of serum high-sensitivity C-reactive protein(Hs-CRP) level between prehypertension patients and normal blood pressure individuals,meantime,some relative other cardiovascular disease risk factors which aggravate inflammation were analyzed.MethodsAccording to 2005 guideline for the preventing and treating hypertension of China,Total cholesterol(TC),serum high-sensitivity C-reactive protein(Hs-CRP),triglyceride(TG),fasting blood glucose(FBG) and body mass index(BMI) were measured in 87 patients with prehypertension(120-139/80-89 mmHg) and 70 normal controls(＜120/80mmHg).Serum high sensitivity C-reactive protein level was measured with enzyme linked immunosorbent assay (ELISA).ResultCompared with normal controls,the Hs-CRP level of SBP120-139mmHg prehypertension patients were significantly higher[(1.40±0.24) mg/L vs(0.93±0.41) ms/L,P＜0.05]. Compared with normal controls,TC,FBG,BMI levels of prehypertension patients were significantly higher(p＜0.05).Spearman ' s correlation analysis showed the H-sCRP levels were positively correlated to the levels of TC,FBG,TG and BMI(All P＜0.05).ConclusionCompared with normal controls,the Hs-CRP level of SBP120-139mmHg prehypertension patients were significantly higher(p＜0.05).It was showed that an inflammation reaction had been involved in prehypertension patients.Cardiovascular disease risk factors were significant different in tow groups.Hs-CRP levels were positively correlated to the levels of TC,FBG,TG and BMI(All P<0.05).Showed that prehypertension group changed not only levels of blood pressure but also cardiovascular disease risk factors and markers of target organ damage. Therefore,the relevant laboratory tests,assessing the target organ damage and cardiovascular disease risk factors,making cardiovascular risk stratification and making rational treatment were done for patients with prehypertension.