The Relationship Study Between The Left Ventricular Structure And Function In Prehypertension With Obesity And High-sensitivity C-reactive Protein In Patients

Objective:To observe pre-obese patients with hypertension,left ventricular structure and function by observing the response of high sensitivity C protein level trends,explore pre-hypertension,obesity,left ventricular structure and function in the mechanism,and to study the relationship between its reactive protein and high sensitivity C. Methods:Select from June 2013 to December 2014,the Second Hospital of Shanxi Medical University Medical Center inpatient and 35-68 year-olds,including 81 cases of prehypertension alone,75 cases of obese patients,obese patients with prehypertension 60 cases.Select the same period in the hospital medical center health examination results were normal age-matched normal control group 45 cases. The selected subjects were recorded as age,sex,smoking,drinking history,requires 12 hours of fasting overnight,the next morning the measurement of height,weight,blood pressure,and calculate body mass index(BMI);determination of TC,TG,LDL-C,HDL-C and FPG conventional biochemical indicators; using latex turbidimetry immune-enhancing measure high-sensitivity C-reactive protein concentrations. Echocardiographic LVIDd,LVIDs,IVST,IVSd,IVSs,LVPWT,PWTd,PWTs, peak early diastolic flow velocity(E),late diastolic peak flow velocity(A),and in accordance with formula to LVMI,m FS,E / A. Results:1. The pre-hypertension with obesity group left ventricular mass index(53.68 ± 10.29 g / m2.7) was significantly higher than pre-hypertension group(41.53 ± 9.64 g / m2.7),obese group(39.98 ± 8.92 g / m2.7) and the control group(28.46 ± 5.73 g / m2.7),and there was statistically significant in differences(P <0.05);simple prehypertension group and obese group were higher left ventricular mass index. There was statistically significant in differences(P <0.05).2. Prehypertension merger obese middle wall shortening(11.73 ± 3.74%) was significantly lower than that prehypertension group(15.81 ± 4.96%),obesity group(15.16 ± 4.23%) and the control group(19.47 ± 4.94 %),and there was statistically significant in differences(P <0.05);simple prehypertension group,the obese group were significantly lower than the normal group,there was statistically significant in differences(P <0.05). Early diastolic and late diastolic filling velocity ratio between the four groups showed no significant difference(P> 0.05).3. Obese hypertensive patients with pre-merger high-sensitivity C-reactive protein concentrations(9.6 ± 0.7mg / L) was significantly higher than pre-hypertension group(6.9 ± 0.5mg / L),obesity group(6.2 ± 0.4mg / L) and the control group(4.1 ± 0.3mg / L),and there was statistically significant in differences(P <0.05);hypertension group,obese group Gao Min C-reactive protein concentration in the normal group,there was statistically significant in differences(P <0.05).4.The factorial analysis showed that pre-hypertension and obesity in left ventricular mass index,middle wall shortening,high-sensitivity C-reactive protein concentration in both interactions.5. Left ventricular mass index and middle wall shortening was significantly negatively correlated(r =-0.783,P <0.05),reactive protein concentration and high-sensitivity C was a significant positive correlation(r = 0.694, P <0.05),was positively correlated with systolic blood pressure(r = 0.951,P <0.05),and diastolic blood pressure levels were positively correlated(r = 0.763,P <0.05);the middle wall shortening and systolic blood pressure levels were negatively correlated(r =-0.695,P <0.05),and diastolic blood pressure levels were negatively correlated(r =-0.894,P <0.05).6. The regression analysis revealed that BMI,SBP,DBP,hs-CRP as the main factors affecting the left ventricular mass index; BMI,systolic blood pressure,diastolic blood pressure,hs-CRP as affecting middle wall shortening the main factor;only the early diastolic and systolic blood pressure is a major factor affecting late diastolic filling velocity ratio.Conclusions:Pre-hypertension,obesity is a risk factor for cardiovascular disease;high blood pressure and obesity can increase the interaction of cardiac dysfunction. High-sensitivity C-reactive protein involved in the pre-hypertension,obesity,cardiac target organ damage in patients.