The Expression Of ENA-78 In Decidual Placental Tissues Of Spontaneous Abortion Mouse Models And LMWH Intervention Spontaneous Abortion Mouse Models

Objective:In order to investigate the pathogenetic mechanism of ENA-78 at the occurrence of spontaneous abortion,We research apoptosis and expression of ENA-78 in decidual placental tissues of spontaneous abortion mouse models,normal pregnancy mouse models and LMWH intervention spontaneous abortion mouse models respectively.The study may provide new ideas for clinical monitoring and treatment of spontaneous abortionMethods:the normal pregnancy mouse models,the spontaneous abortion mouse models and the Heparin intervention mouse models were established.Immunohistochemistry SABC method was adopted to detect the expression of ENA-78 of Placenta tissue at the day 14 of gestation.Experimental data of statistical methods:Measurement data using one-way ANOVA and t test;Count data using _X2 test.Results:(1) The ENA-78 positive rate in decidual placental tissues of spontaneous abortion mouse models was significantly higher than that of normal pregnancy mouse models(P＜0.01).(2) The ENA-78 positive rate in decidual placental tissues of spontaneous abortion mouse models was significantly higher than that of LMWH intervention spontaneous abortion mouse models(P＜0.01).(3) The ENA-78 positive rate in decidual placental tissues of normal pregnancy mouse models was Similar with that of LMWH intervention spontaneous abortion mouse models (P＞0.05).Conclusions:the express of ENA-78 in placental tissue was increased,So the abnormal expression of ENA-78 may be one of the mechanisms of spontaneous abortion,the expression of ENA-78 reduced withr LMWH intervention,so LMWH may play a role in spontaneous abortion prevention and treatment.