Study On The Relationship Between Anxiety And The Invasion Of Cardiovascular Heart Disease And TCM Syndrome Patterns

Objective:To analyze the relationship between anxiety and coronary heart disease,and explain the mechanism and the key role of the anxiety that induces the coronary heart disease.To discuss the differences between TCM syndrome patterns in coronary heart disease patients with anxiety disorder,and establish risk factors for CHD with anxiety,in order to find the objective evidence for CHD with anxiety and symptom differentiation.Methods:60 healthy Wistar rats were randomly divided into 4 groups,Except for the normal control group(NC),high-fat control group(HFC) and anxiety high-fat control group(AHFC) were lavaged by fat emulsion to establish the hyperlipemia model,and empty water bottles stress were given to anxiety control group(AC) and anxiety high-fat control group(AHFC) for establishing emotional stress models with the main manifestation of anxiety.TC,TG,LDL-C and HDL-C in serum of rats were detected respectively.The experimental acute myocardial ischemia model was establish by the intraperitoneal injection of pituitrin to rats and the electrocardiogram was recorded,CK,CK-MB,LDH in serum of rats were detected,myocardial pathological changes of Heart tissue with HE stain were observed.Seventy-two CHD patients were divided into 6 groups through the TCM differentiation,there are 17 pertaining to the cariac blood stasis,22 obstruciton of turbid phlegm,2 stagnation of Yin-cold,8 both kidney and heart Yin deficiency,19 both Qi and Yin deficiency,2 Yang deficiency. Inducing the regularities of TCM syndrome patterns.Analyzing the correlation of risk factors of CHD,anxiety and TCM syndrome patterns.Results:1.The TCH,TG,LDL-C of HFC were significant higher than NC and AC(P<0.01);TCH and LDL-C of AHFC were significant higher than any other group(P<0.05-0.01);there was significant difference of TG and LDL-C between AC and NC.2.CK,CK-MB,LDH of AHFC and HFC were significant higher than NC(P＜0.05-0.01),and AHFC was higher than HFC in CK,CK-MB(P＜0.05);CK-MB of AC was higher than NC significantly(P＜0.05).3.There were statistic differences in the range of EKG J dot changes between AHFC and NC in 6 points of time(P＜0.05-0.01),significant difference in 4 and 5 points of time compared with HFC and AC respectively(P＜0.05);J dot of AC and HFC were higher than NC from the second minute on(P＜0.05).4.In terms of myocardial damages such as cadiocyte cloudy swelling, myofilament break and cytonecrosis,significant differences are found between NC and the other three groups,among which the most serious one is reflected in AHFC(P＜0.01);inflammatory cell infiltration was severe in HFC and AHFC,and then the AC(P＜0.01);there were statistic differences between all of the groups in interstitial edema,haemorrhage and small vessels haemostasis(P＜0.05).5.There was obvious statistic diferences of TCM syndrome patterns among gender,age,BMI,anxiety degree and smoking hi story(P＜0.05).There was correlation between TCM syndrome patterns and gender,body weight index, degree of anxiety and smoking history(P＜0.05),among which there was negative correlation of anxiety degree,positive correlation of others.6.The incidence of anxiety was 52.8%among CHD patients,of which there are more females(P＜0.01),but patients mostly have normal body weight index(P＜0.05);anxiety degree was negatively correlated with gender and body weight index(P＜0.01).Conclusion:1.Anxiety may affect the lipid metabolism,induce coronary atherosclerosis, and aggravate myocardial ischemia and damage.2.Risk factors of CHD such as gender,age,body weight index and smoking history has certain correlation with TCM syndrome patterns.3.There is certain correlation between anxiety and TCM syndrome patterns.The TCM pathogenesis of anxiety inducing CHD is both Qi and Yin deficiency and cariac blood stasis.Gender and body weight index are major risk factors of CHD patients with anxiety.