Research On The TCM Syndrome Type Distribution In CIN And The Relationship Between CIN TCM Syndrome Types And High Risk HPV Infection

ObjectiveThe aim of this study was to explore the TCM syndrome type distribution in CIN.To research the relationship between CIN patients with different types of syndrome and high risk HPV infection,including different subtypes.In order to provide a theoretical evidence for the prevention and treatment with traditional Chinese medicine in CIN.Methods169 cases of CIN patients were chosen,aged between 21 to 62 years old.The average age of the patients was 30.55±10.31 years old.The patients were divided into four groups according to the standard of the CIN syndrome differenciation and clinical observation table:spleen deficiency,kidney deficiency,damp-heat and damp-toxin.The TCM syndrome type distribution in CIN was sumed up.54 cases of these CIN patients were detected by HPV DNA types through prospective research.The relationship between CIN patients with different types of syndrome and high risk HPV infection were analyzed,including different subtypes.Results1 Integrating retrospective investigation and prospective clinical obser -vation,the proportions of each TCM syndrome type among all the patients were as follows:spleen deficiency 21.89%,kidney deficiency 16.57%,damp-heat 53.25%,damp-toxin 8.28%.Damp-heat＞spleen deficiency＞kidney deficiency＞damp-toxin.2 There was no significant difference among the four groups of TCM syndrome types in infection rate of high risk HPV(P＞0.05).There was no significant difference among the four groups of TCM syndrome types in multiple infection rate of HPV(P＞0.05). 3 There wao no close relationship between the four different TCM syndrom types in CIN and high risk HPV subtypes(P＞0.05).4 The comparison of the distribution of four TCM syndrome types between the infection of high risk HPV16 and HPV58 indicated significant difference (P＜0.05).Among the patients with the infection of HPV16,the proportion of each group of TCM syndrome types were as follows:spleen deficiency 24%,kidney deficiency 4%,Damp-heat 76%,damp-toxin 12%.Damp-heat＞spleen deficiency＞damp-toxin＞kidney deficiency.The percentage was significantly different among the four TCM syndrome types(P＜0.05).There were significant differences between kidney deficiency and spleen deficiency,kidney deficiency and damp-heat (P＜.05).No significant difference was found between another two types (P＞0.05).While among the patients with the infection of HPV58:spleen deficiency accounting for 25%,kidney deficiency accounting for 31.25%,damp-heat accounting for 37.5%,damp-toxin accounting for 6.75%.Damp-heat＞kidney deficiency＞spleen deficiency＞damp-toxin.The comparison of every two syndrome types did not show any differences among the four TCM syndrome types(P＞0.05).ConclusionThe research found a distribution of TCM syndrome types in CIN that damp-heat is the most common clinical syndrome type,as spleen deficiency and kidney deficiency followed by,damp-toxin the least.There is no significant difference in high risk HPV infection rate among the four groups of TCM syndrome types,either is in multiple HPV infection rate.The result showed that the four different TCM syndrom types in CIN may not be closely related to the high risk HPV subtypes.High risk HPV16 and HPV58 are the main HPV subtypes in these four groups of TCM syndrome types.Significant difference is found between HPV16 and HPV58 infection in the distribution of these four TCM syndrome types.