The Value Of Telomerase Gene In Predicting The Outcome Of Mild Cervical Intraepithelial Neoplasia

Objective:To study the expressions of the human telomerase RNA (hTERC) gene in low-grade cervical intraepithelial neoplasia (CIN1) in patients, and the outcome of the cases.The aim of this study is to evaluate the clinical value of this indicator in predicting the outcome of mild cervical intraepithelial neoplasia (CIN1) in patients.Methods:Fluorescence in situ hybridization technique was used to detect the expression of hTERC gene in 118 cases of mild cervical intraepithelial neoplasia (CIN1) in patients. All patients were choosed from the outpatients of the affiliated Gulou hospital of Nanjing University from January 2010 to April 2011.The surgical group included 56 patients who accepted the cervical electrosurgical excision procedure,the others were included in the control group.All patients were followed up for 2 years.every 6 to 12 months, using liquid-based cytology and high-risk HPV test (HC-Ⅱ),Colposcopy and biopsies were performed when the cervical cytology indicated as ASCUS or more severe lesion and/or HR-HPV positive.Results:1、After 24 months’ follow-up,1 patients was lost,2 were rejected,and the other 115 ones (97.46%) finished the whole study.2、The progression to high-grade CIN rate of the hTERC gene positive group was higher then the rate of the hTERC gene negative group.3、The cervix fiberotomy can improve the prognosis of the hTERC gene positive patients with mild cervical intraepithelial neoplasia.Conclusion:1、hTERC gene can predict the outcome of mild cervical intraepithelial neoplasia in patients,so it might be an indicator for those patients.2、The patients with positive hTERC gene have higher high-risk HPV overcast than the hTERC gene negative group.3、Which application of cervical LEEP operation,that can improve the prognosis of the patients.