Studies On Chemical Constituents Of Schima Superba

Mu He(Schima superba Gardn.et Champ.),alternately named as He Shu,Mu Ai Shu and He Mu in chinese,is widely destributed in Fujian,Jiangshu,Zhejian,Anhui and other provinces in south china.Although it is known that the plant has been used as a source of timber,and that its root bark has been used as a traditional chinese herb to treat furuncle and some kind of sore,little chemical work has been reported. Based on the cytotoxicity of its 95%alcoholic extract of the stem and the CHCl₃ and EtOAc fractions from the extract against a few cancer cell lines,we had systematically investigated the chemical constituents on both the fractions from Schima superba.25 compounds had been isolated from the fractions.By means of spectroscopic techniques as well as physical and chemical properties,the structures of 22 compounds were elucidated as 2,6-dimethoxybenzoquinone(1),2,4,6-trimethoxy -phenol(2),syringic acid(3),coniferyl aldehyde(4),syringaldehyde(5),Albarrigenol (6),camelliagenin A(7),barringtogenol C(8),syringaresinol(9), pinoresinol(10),lariciresinol(11),balanophonin(12),3-acetoxymethyl-5-[(E)-2-for -mylethen-1-yl]-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-2,3-dihydro benzo furan (13),dihydrodehydrodiconifery alcohol(14),4,9-dihydroxy-3,3'-dimethoxy-4',7-epoxy-8,5'-neolignane-9'-yl acetate(15),isolariciresinol(16),(7R,8S)-l-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol (17),acernikol(18),kaempferol(19),quercetin-3-O-β-D-glucopyranoside(20), quercetin-3-O-β-D-galactopyranosde(21) and schimanin(22).Among these compounds,compound 22 is a new lignin,and all the others are for the first time isolated from this plant and from Schima.except compound 6.